Silver accumulation and ionomic profile alterations in pigs
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
ACS Agricultural Science & Technology
Exportar
Resumo
The antimicrobial properties of silver nanoparticles (AgNPs) in animal feed have drawn increasing attention as a
potential alternative to antibiotics. However, concerns about bioaccumulation and possible effects on mineral homeostasis require a
thorough evaluation. This study investigates the bioaccumulation of Ag in various tissues and ionomic alterations in pigs fed AgNPs
complexed with carbohydrates (AgNPs@Carb). Silver concentrations were measured in tissues, such as the liver, kidney, spleen,
heart, and cecal contents, at different time points following the withdrawal of the nanoparticle-supplemented diet. Principal
component analysis (PCA) assessed the concentrations of 18 elements across 10 tissues. Results indicate that silver primarily
accumulates in the liver and cecal contents, with varying clearance rates across tissues. The silver estimated daily intake (EDI) for
human consumption was evaluated, revealing low values across all tissues. This suggests that potential exposure to Ag through the
consumption of edible tissues from animals supplemented with AgNPs is minimal and does not pose an immediate health risk.
Significant changes were also observed in the ionomic profiles, suggesting that AgNPs disrupt trace element homeostasis. These
findings underscore the importance of understanding both the biodistribution of silver nanoparticles and their potential long-term
impact on animal health and human consumers.
Como referenciar
SANTANA, BIANCA de M.; TREMILIOSI, GUILHERME C.; BATISTA, BRUNO L.; MONTEIRO, LUCILENA R.; SEABRA, AMEDEA B.; GONCALVES, JOAQUIM C.A.; SILVEIRA, HEBERT; COELHO, FLAVIO de A.; ALVES, LAYA K.S.; GARBOSSA, CESAR A.P.; LANGE, CAMILA N. Silver accumulation and ionomic profile alterations in pigs: evaluation of silver nanoparticles as feed supplements and potential human exposure. ACS Agricultural Science & Technology, v. 5, n. 4, p. 513-522, 2025. DOI: 10.1021/acsagscitech.4c00624. Disponível em: https://repositorio.ipen.br/handle/123456789/49365. Acesso em: 04 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.