In vitro biocompatibility of new bioactive lithia-silica glass-ceramics
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Materials Science & Engineering C
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Glass-ceramics based on the Li2O-SiO2 system have been extensively used as restorative dental materials due to
their excellent chemical durability, aesthetics, inertness in the buccal environment, and high fracture strength;
but they are not bioactive. On the other hand, all known bioactive glasses show ability to bond to bone, teeth and
cartilage coupled to osteoconduction and osteoinduction, but their fracture strength and toughness are rather
low. The aim of this study is to develop and evaluate the in vitro biocompatibility of a new type of (bioactive and
strong) lithia-silica glass-ceramic. For these purposes, two types of glass-ceramics based on a multicomponent
lithia-silica system were studied: lithium metasilicate (LM) and lithium disilicate (LD). The in vitro bioactivity
study was conducted in a SBF solution, before and after different times of immersion; the new materials were
analyzed by XRD, FTIR, and SEM. Some samples were subjected to in vitro biodegradation tests to quantify the
release of lithium and the weight loss. Cytotoxicity, adhesion, and cell proliferation on different samples were
examined by using the Methyl Tetrazolium salt (MTS) and Alizarin Red. For ~40 vol% crystallinity, lithium
metasilicate was detected as the major phase, whereas for ~80 vol% crystallinity, lithium disilicate was the
major phase. The LD proved to be strong (3p-bending strength of 233 ± 12 MPa) and bioactive after 14 days of
immersion in SBF. In terms of lithium ion release, the LD was outside the toxic range (> 8.3 ppm). The LM and
LD are not cytotoxic. The LD shows the best cellular adhesion and proliferation, leading to the formation of a
mineralized matrix after 21 days. These results clearly suggest that the new LD brand is strong and highly
biocompatible and warrants further study.
Como referenciar
DAGUANO, JULIANA K.M.B.; MILESI, MARIANA T.B.; RODAS, ANDREA C.D.; WEBER, ALINE F.; SARKIS, JORGE E.S.; HORTELLANI, MARCOS A.; ZANOTTO, EDGAR D. In vitro biocompatibility of new bioactive lithia-silica glass-ceramics. Materials Science & Engineering C, v. 94, p. 117-125, 2019. DOI: 10.1016/j.msec.2018.09.006. Disponível em: http://repositorio.ipen.br/handle/123456789/29994. Acesso em: 26 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.