Lack of associated between matrix metalloproteinase-I (MMP-1) promoter polymorphism and risk of renal cell carcinoma
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International Brazilian Journal Urology
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OBJECTIVE: Investigate the possible association of insertion/deletion (2G/G) polymorphism at nucleotide -1607 of the MMP-1 promoter with the development and progression of renal cancer MATERIALS AND METHODS: In this study, we genotyped 217 individuals, 99 patients with renal cell carcinoma (RCC) and 118 controls without cancer. DNA specimens were extracted from epithelial buccal cells and paraffin-embedded tissue of RCC patients and from epithelial buccal cells and blood cells of healthy controls RESULTS: The difference in frequency of 2G/2G genotype between controls (22.9%) and RCC patients (28.6%) was not statistically significant (p = 0.461). We also did not find correlation between 2G/2G and histological type of RCC. The comparison of genotype distribution and frequency of 2G allele in different populations showed a strong variability of 2G allele frequency among the different ethnic groups. This fact may influence on the collaboration of this 2G allele in RCC or others diseases CONCLUSION: Our data suggest that the matrix metalloproteinase-1 (MMP-1) promoter polymorphism may not play a significant role in renal cell carcinoma patients in Brazil.
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PICCOLI, MICHELLY F.; FIGUEIRA, M.; ANDREONI, CASSIO; MARUMO, JULIO T.; SCHOR, NESTOR; BELLINI, MARIA H. Lack of associated between matrix metalloproteinase-I (MMP-1) promoter polymorphism and risk of renal cell carcinoma. International Brazilian Journal Urology, v. 33, n. 5, p. 622-629, 2007. DOI: 10.1590/S1677-55382007000500003. Disponível em: http://repositorio.ipen.br/handle/123456789/5201. Acesso em: 27 Mar 2026.
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