Quantitative analysis of light elements using compact XRF spectrometers

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dc.contributor.authorZAMBONI, CIBELE B.
dc.contributor.authorSILVA, DALTON G.N. da
dc.contributor.authorMORGADO, RAFAEL S.
dc.contributor.authorZANATA, THIAGO
dc.contributor.authorLEAL, LUIS G.M.
dc.contributor.authorMOREIRA, DAVISON de M.
dc.coverageInternacionalpt_BR
dc.creator.eventoRIO SYMPOSIUM ON ATOMIC SPECTROMETRY, 14thpt_BR
dc.date.accessioned2017-07-10T16:10:34Z
dc.date.available2017-07-10T16:10:34Z
dc.date.evento02-07 de abril, 2017pt_BR
dc.description.abstractThe use of analytical techniques to investigate specific ions in body fluids has increase in last year’s presenting significant progress in clinical tests. This motivated us to check the performance of two compacts XRF spectrometers (X-123SDD, Amptek) consisting of Ag and Au X-ray mini-tubes associated with a Si Drift detector (25 mm2 x 500 μm) with Be window (12.5 μm) for this clinical finality. Using the Energy Dispersive X-Ray Fluorescence technique (EDXRF) specific ions of clinical relevance, such as, Ca, Cl, Fe and K were investigated using standards (certified solutions). A simplified sample preparation procedure was proposed, i.e., the liquid samples were dripped in filter paper (Whatman, n° 41) and dried for a few seconds using infrared lamp and dry for few seconds using infrared lamp. The performance of these spectrometers were checked by evaluation of several parameter (linearity, reproducibility, accuracy, precision, sensitivity and detection limit) usually considered for validation procedures on analytical methods, in according to ISO 17025 and EURACHEM/CITAC norms. For simultaneous determination of these ions, the optimized excitation condition was established by 300s using 5μA and 30kV. The method was proved to give reliable results with limits of detection at levels of 0.23 to 0.58 mgL−1 for. Considering that the ranges of the body fluids, such as: blood, saliva, serum and urine, are in the order of hundreds of mg L-1, this procedure is very promising for ions dosage requiring a small amount of sample (50μL, 10 times less comparatively to the conventional tests), simultaneous analysis, short time of analysis (minutes) and simple sample preparation. In addition, this procedure offers a non-destructive alternative for clinical usage. Finally, these compact spectrometers have potential use when the biological material is scarce, case of the pediatric practice in newborns and premature infants (blood collection is the main cause of transfusions) and in vivo tests, in small size animal model (mice and rats), in order to evaluate the safety of new drugs, vaccines and others medical supplies.pt_BR
dc.identifier.citationZAMBONI, CIBELE B.; SILVA, DALTON G.N. da; MORGADO, RAFAEL S.; ZANATA, THIAGO; LEAL, LUIS G.M.; MOREIRA, DAVISON de M. Quantitative analysis of light elements using compact XRF spectrometers. In: RIO SYMPOSIUM ON ATOMIC SPECTROMETRY, 14th, 02-07 de abril, 2017, Vitória, ES. <b>Abstract...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/27662.
dc.identifier.orcidhttps://orcid.org/0000-0001-7766-2692
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27662
dc.local.eventoVitória, ESpt_BR
dc.rightsopenAccesspt_BR
dc.titleQuantitative analysis of light elements using compact XRF spectrometerspt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorRAFAEL SOZONOV MORGADO
ipen.autorLUIS GUILHERME MASSAKI LEAL
ipen.autorDALTON GIOVANNI NOGUEIRA DA SILVA
ipen.autorCIBELE BUGNO ZAMBONI
ipen.codigoautor14439
ipen.codigoautor14304
ipen.codigoautor13948
ipen.codigoautor267
ipen.contributor.ipenauthorRAFAEL SOZONOV MORGADO
ipen.contributor.ipenauthorLUIS GUILHERME MASSAKI LEAL
ipen.contributor.ipenauthorDALTON GIOVANNI NOGUEIRA DA SILVA
ipen.contributor.ipenauthorCIBELE BUGNO ZAMBONI
ipen.date.recebimento17-07pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc23905pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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relation.isAuthorOfPublicationefc34383-9bc0-4a23-ab04-8e2606a30741
relation.isAuthorOfPublicationbc63fe9c-45a3-4902-9c00-76b77f4a74d2
relation.isAuthorOfPublication563d95e5-227e-456d-a1d7-4bb051ae51ba
relation.isAuthorOfPublication.latestForDiscovery563d95e5-227e-456d-a1d7-4bb051ae51ba
sigepi.autor.atividadeZAMBONI, CIBELE B.:267:310:Spt_BR
sigepi.autor.atividadeSILVA, DALTON G.N. DA:13948:310:Npt_BR
sigepi.autor.atividadeMORGADO, RAFAEL S.:14439:-1:Npt_BR
sigepi.autor.atividadeLEAL, LUIS G.M.:14304:310:Npt_BR
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