Natural polymer hydrogels with gold nanoparticles for bladder cancer chemotherapy delivery

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dc.contributor.authorLIMA, C.S.A.pt_BR
dc.contributor.authorVARCA, G.pt_BR
dc.contributor.authorDE FREITAS, L.F.pt_BR
dc.contributor.authorVARCA, J.O.pt_BR
dc.contributor.authorLUGAO, A.B.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoWORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6thpt_BR
dc.date.accessioned2020-10-27T18:25:02Z
dc.date.available2020-10-27T18:25:02Z
dc.date.eventoOctober 29-31, 2019pt_BR
dc.description.abstractThe treatment of bladder cancer is done by transurethral resection for tumor removal, followed by immune or chemotherapy intravesical, according to the stage of the disease. The main objective of this work was to develop and characterize strategies to increase the residence time and specificity of chemotherapy through the application of hydrogels for chemotherapy and /or immunotherapy administration. Natural polymers gellan gum and microcrystalline cellulose were chosen to prepare the hydrogels as they are already widely used in the biomedical area due to characteristics such as the absence of toxicity, high biocompatibility, and biodegradability. Papain-coated gold nanoparticles were added to the gels to promote chemo or immunotherapeutic permeation. Preliminary stability assays were carried out to evaluate the compatibility between the polymeric matrices and the gold nanoparticles. The systems were characterized by Scanning Electron Microscopy, and Fourier Transform Infrared Spectroscopy. The results allowed the identification of the polymer groups present in the formulations, as well as the evaluation of the interactions between the hydrogel network and the nanoparticles. The formulations were suitable for the proposed application.pt_BR
dc.event.siglaOBIpt_BR
dc.format.extent127-127pt_BR
dc.identifier.citationLIMA, C.S.A.; VARCA, G.; DE FREITAS, L.F.; VARCA, J.O.; LUGAO, A.B. Natural polymer hydrogels with gold nanoparticles for bladder cancer chemotherapy delivery. In: WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th, October 29-31, 2019, São Paulo, SP. <b>Abstract...</b> p. 127-127. Disponível em: http://repositorio.ipen.br/handle/123456789/31554.
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcid0000-0002-6545-237Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31554
dc.local.eventoSão Paulo, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleNatural polymer hydrogels with gold nanoparticles for bladder cancer chemotherapy deliverypt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorLUCAS FREITAS DE FREITAS
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorCAROLINE SANTOS ALVES DE LIMA
ipen.codigoautor14818
ipen.codigoautor339
ipen.codigoautor8726
ipen.codigoautor8661
ipen.codigoautor14945
ipen.contributor.ipenauthorLUCAS FREITAS DE FREITAS
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorCAROLINE SANTOS ALVES DE LIMA
ipen.date.recebimento20-10
ipen.event.datapadronizada2019pt_BR
ipen.identifier.ipendoc27326pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication05be75ae-89a2-47f4-a13a-7723b50a6bd0
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublicatione31cd2b4-ae29-47a5-aa35-ba3e58cdeb92
relation.isAuthorOfPublication46f998cf-b207-4854-94c0-dd2def4eec2a
relation.isAuthorOfPublication00496d62-f664-40ae-bf64-e0db91a39f77
relation.isAuthorOfPublication.latestForDiscovery00496d62-f664-40ae-bf64-e0db91a39f77
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
sigepi.autor.atividadeVARCA, J.O.:8726:740:Npt_BR
sigepi.autor.atividadeDE FREITAS, L.F.:14818:750:Npt_BR
sigepi.autor.atividadeVARCA, G.:8661:750:Npt_BR
sigepi.autor.atividadeLIMA, C.S.A.:14945:-1:Spt_BR
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