Influence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels

Página do item simplificado
dc.contributor.authorSEPULVEDA, ANDERSON F.
dc.contributor.authorSILVA, JESSICA B. da
dc.contributor.authorBRUSCHI, MARCOS L.
dc.contributor.authorFRANCO, MARGARETH K.K.D.
dc.contributor.authorYOKAICHIYA, FABIANO
dc.contributor.authorTOFOLI, GIOVANA R.
dc.contributor.authorCEREDA, CINTIA M.S.
dc.contributor.authorROSSO, ANABELLA P.
dc.contributor.authorGIACOMELLI, FERNANDO C.
dc.contributor.authorSCOTT, ANA L.
dc.contributor.authorARAUJO, DANIELE R. de
dc.coverageInternacional
dc.date.accessioned2024-12-16T19:17:19Z
dc.date.available2024-12-16T19:17:19Z
dc.date.issued2024
dc.description.abstractNew pharmaceutical formulations have been proposed as strategies to improve transport and provide best conditions to control the drug release rate in specific biological environments, such as mucosa surfaces. Herein, formulations containing binary systems Poloxamer (PL) 407 15 % and PL 338 15 %, combined with hyaluronic acid, carrying the local anesthetic bupivacaine (BVC), were studied by molecular dynamics, while other structural parameters were determined by Dynamic Light Scattering for stablishing relationships with mucoadhesive properties and cytotoxicity evaluation. The binary system PL 407 15 %/PL 338 15 % exhibited a well-organized structural morphology, with more hydrated corona, and increased mucoadhesive properties over mucin layers. After hyaluronic acid (HA) incorporation, it was observed an increase on the force of detachment, possibly due to HA role as a linker among mucin layers independently of PL supramolecular structures. On the other hand, the addition of BVC or HA/BVC into the binary system decreased the force of detachment, as a response of augmented of compactness of these hydrogels caused by desolvation of PO core, showing the influence of all components and their chemical interactions into the structural organization and their biopharmaceutical performance relationships.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 14/14457-5; 19/20303-4; 21/12071-6; 22/14668-2; 23/13068-4
dc.description.sponsorshipIDCNPq: 308819/2022-5
dc.description.sponsorshipIDCAPES: 001
dc.format.extent1-13
dc.identifier.citationSEPULVEDA, ANDERSON F.; SILVA, JESSICA B. da; BRUSCHI, MARCOS L.; FRANCO, MARGARETH K.K.D.; YOKAICHIYA, FABIANO; TOFOLI, GIOVANA R.; CEREDA, CINTIA M.S.; ROSSO, ANABELLA P.; GIACOMELLI, FERNANDO C.; SCOTT, ANA L.; ARAUJO, DANIELE R. de. Influence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels: from molecular modelling to biointerfaces interactions. <b>Colloids and Surfaces A: Physicochemical and Engineering Aspects</b>, v. 698, p. 1-13, 2024. DOI: <a href="https://dx.doi.org/10.1016/j.colsurfa.2024.134527">10.1016/j.colsurfa.2024.134527</a>. Disponível em: https://repositorio.ipen.br/handle/123456789/48792.
dc.identifier.doi10.1016/j.colsurfa.2024.134527
dc.identifier.issn0927-7757
dc.identifier.percentilfi65.4
dc.identifier.percentilfiCiteScore76.00
dc.identifier.urihttps://repositorio.ipen.br/handle/123456789/48792
dc.identifier.vol698
dc.relation.ispartofColloids and Surfaces A: Physicochemical and Engineering Aspects
dc.rightsopenAccess
dc.titleInfluence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels
dc.typeArtigo de periódico
dspace.entity.typePublication
ipen.autorMARGARETH KAZUYO KOBAYASHI DIAS FRANCO
ipen.codigoautor9803
ipen.contributor.ipenauthorMARGARETH KAZUYO KOBAYASHI DIAS FRANCO
ipen.identifier.fi4.9
ipen.identifier.fiCiteScore8.7
ipen.identifier.ipendoc30845
ipen.identifier.iwosWoS
ipen.range.fi4.500 - 5.999
ipen.range.percentilfi50.00 - 74.99
ipen.subtitulofrom molecular modelling to biointerfaces interactions
ipen.type.genreArtigo
relation.isAuthorOfPublicationea01b86e-8435-405e-874c-d0b68fb2b549
relation.isAuthorOfPublication.latestForDiscoveryea01b86e-8435-405e-874c-d0b68fb2b549
sigepi.autor.atividadeMARGARETH KAZUYO KOBAYASHI DIAS FRANCO:9803:1120:N
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
30845.pdf
Tamanho:
4.09 MB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar
Coleções
Periódicos