Exposure to crack cocaine causes adverse effects on marine mussels Perna perna
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Marine Pollution Bulletin
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Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perna. For
this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand
breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h
(IC50 =23.53 mg·L−1) and 48 h (IC50 =16.31 mg·L−1), respectively. The highest tested concentration showing
no acute toxicity (NOEC) was 10 mg·L−1, while the lowest observed effect concentration (LOEC) was 20 mg·L−1.
NOEC concerning embryo-larval development was 0.625 mg·L−1, while the LOEC was 1.25 mg·L−1. Cyto-genotoxic
effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 μg·L−1.
Our results report the first data on effects of an illicit drug to marine organisms and should encourage further
ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems.
Como referenciar
MARANHO, L.A.; FONTES, M.K.; KAMIMURA, A.S.S.; NOBRE, C.R.; MORENO, B.B.; PUSCEDDU, F.H.; CORTEZ, F.S.; LEBRE, D.T.; MARQUES, J.R.; ABESSA, D.M.S.; RIBEIRO, D.A.; PEREIRA, C.D.S. Exposure to crack cocaine causes adverse effects on marine mussels Perna perna. Marine Pollution Bulletin, v. 123, n. 1-2, p. 410-414, 2017. DOI: 10.1016/j.marpolbul.2017.08.043. Disponível em: http://repositorio.ipen.br/handle/123456789/28460. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.