Toxicity removal of pharmaceuticals mixtures through electron beam irradiation

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dc.contributor.authorBOIANI, N.F.pt_BR
dc.contributor.authorTOMINAGA, F.K.pt_BR
dc.contributor.authorBORRELY, S.I.pt_BR
dc.coverageNacionalpt_BR
dc.date.accessioned2022-12-20T15:30:33Z
dc.date.available2022-12-20T15:30:33Z
dc.date.issued2022pt_BR
dc.description.abstractContamination of the aquatic environment by pharmaceuticals is becoming a global phenomenon of growing concern. Pharmaceuticals are partially metabolized, resulting in the excretion and release of residual into sewage, unaltered or metabolites. The wastewater treatment plants are not designed to eliminate these compounds, leading the residues into the aquatic environment. Besides, pharmaceuticals are not detected individually but as a complex mixture. Advanced oxidative processes have been applied as an alternative or complement to conventional sewage treatment processes, aiming the degradation and removal of toxic pollutants. The objective of this study was to evaluate the toxicity removal of mixtures of pharmaceuticals subjected to electron beam treatment. The aqueous solutions of each pharmaceutical were diluted in ultra-pure water and prepared in three pharmaceuticals combinations: Propranolol + Fluoxetine + Sulfadiazine; Propranolol + Fluoxetine + Diclofenac; Acetylsalicylic acid + Fluoxetine + Metformin). Electron Beam Accelerator was applied for the irradiations and the absorbed doses were 2.5-5.0 kGy. Acute toxicity tests with Daphnia similis were performed to evaluate the toxicity, before and after irradiation.. The data analyzed showed toxicity removal efficiency around 80% for the mixture of Propranolol, Fluoxetine and Diclofenac; 75% for the mixture of Propranolol, Fluoxetine and Sulfadiazine; and 30% for the mixture of Acetylsalicylic acid, Fluoxetine and Metformin. According to the literature, this is a viable technology for the removal of toxicity from pharmaceuticals, and the results demonstrated the potential of electron beam irradiation in reducing the toxicity of pharmaceutical from different classes.pt_BR
dc.format.extent1-11pt_BR
dc.identifier.citationBOIANI, N.F.; TOMINAGA, F.K.; BORRELY, S.I. Toxicity removal of pharmaceuticals mixtures through electron beam irradiation. <b>Brazilian Journal of Radiation Sciences</b>, v. 10, n. 3B, p. 1-11, 2022. DOI: <a href="https://dx.doi.org/10.15392/2319-0612.2022.1838">10.15392/2319-0612.2022.1838</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33511.
dc.identifier.doi10.15392/2319-0612.2022.1838pt_BR
dc.identifier.fasciculo3Bpt_BR
dc.identifier.issn2319-0612pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.percentilfiCiteScoreSem Percentil CiteScorept_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33511
dc.identifier.vol10pt_BR
dc.relation.ispartofBrazilian Journal of Radiation Sciencespt_BR
dc.rightsopenAccesspt_BR
dc.sourceMeeting on Nuclear Applications (ENAN), 15th, November 29 - December 2, 2021, Onlinept_BR
dc.subjectaquatic ecosystems
dc.subjectcontamination
dc.subjectdrugs
dc.subjectelectron beams
dc.subjectenvironmental impacts
dc.subjectpollutants
dc.subjectradiation dose units
dc.subjecttoxicity
dc.subjectwaste water
dc.titleToxicity removal of pharmaceuticals mixtures through electron beam irradiationpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorFLAVIO KIYOSHI TOMINAGA
ipen.autorSUELI IVONE BORRELY
ipen.autorNATHALIA FONSECA BOIANI
ipen.codigoautor12754
ipen.codigoautor150
ipen.codigoautor12769
ipen.contributor.ipenauthorFLAVIO KIYOSHI TOMINAGA
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.contributor.ipenauthorNATHALIA FONSECA BOIANI
ipen.date.recebimento22-12
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.fiCiteScoreSem CiteScorept_BR
ipen.identifier.ipendoc29145pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublication4a6f0d4a-15b9-410c-ac91-b72055559f15
relation.isAuthorOfPublication.latestForDiscovery4a6f0d4a-15b9-410c-ac91-b72055559f15
sigepi.autor.atividadeBORRELY, S.I.:150:220:Npt_BR
sigepi.autor.atividadeTOMINAGA, F.K.:12754:220:Npt_BR
sigepi.autor.atividadeBOIANI, N.F.:12769:220:Spt_BR
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