Knee radiosynovectomy with Sm-153 hydroxyapatite compared to Y-90 hydroxyapatite
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European Journal of Nuclear Medicine and Molecular Imaging
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Aim/Introduction: Introduction: The most common
clinical presentation in hemophilia patients consists of
hemarthrosis. Various treatment strategies aim to control
hemarthrosis to prevent secondary arthropathy, among
them, radiosynovectomy with Y-90 hydroxyapatite (90YHA).
A few studies have shown a lower efficiency of knee
radiosynovectomy with Sm-153 hydroxyapatite (153Sm-
HA) compared to 90Y-HA. Purpose: The purpose of this
investigation was to assess the efficacy and safety of knee
radiosynovectomy with 153Sm-HA compared to 90Y-HA.
Materials and Methods: Forty patients were prospectively
assigned to undergo knee radiosynovectomy with 153Sm-
HA (19 patients) or with 90Y-HA (21 patients). The frequency
of hemarthrosis episodes before and after treatment was
compared. Results: The response to knee radiosynovectomy
stratifying according to radiotracer showed that after 6
months the median response rate with 153Sm-HA was not
significantly different from 90Y-HA (87.5% vs 80.9%; p = 0.576).
However, after 12 months the median response rate of knee
radiosynovectomy with 153Sm-HA was significantly better
than with 90Y-HA (87.5% vs 50%; p = 0.037), respectively. The
reduction of joint bleeding by at least 50%, after 12 months,
was greater in the group of patients treated with 153Sm-HA
compared to 90Y-HA (74% vs 52%), respectively. Conclusion:
Knee radiosynovectomy with high doses of 153Sm-HA is
safe, with an efficiency rate similar that is described in the
literature by the 90Y-HA.
Como referenciar
ETCHEBEHERE, E.; LIMA, M.; PEREIRA, L.; PAGNANO, R.; BORTOLETTI, E.; MENGATTI, J.; BRUNETTO, S.Q.; TAKAHASHI, M.; BRUNETTO, E.; OZELO, M.; SANTOS, A. Knee radiosynovectomy with Sm-153 hydroxyapatite compared to Y-90 hydroxyapatite: initial results of a prospective trial. European Journal of Nuclear Medicine and Molecular Imaging, v. 47, p. S628-S628, 2020. Supplement 1. DOI: 10.1007/s00259-020-04988-4. Disponível em: http://repositorio.ipen.br/handle/123456789/32698. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.