Poloxamer 407/188 binary thermosensitive hydrogels as delivery systems for infiltrative local anesthesia: Physico-chemical characterization and pharmacological evaluation
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Materials Science and Engineering C
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In this study,we reported the development and the physico-chemical characterization of poloxamer 407 (PL407)
and poloxamer 188 (PL188) binary systems as hydrogels for delivering ropivacaine (RVC), as drug model, and investigate
their use in infiltrative local anesthesia for applications on the treatment of post-operative pain. We
studied drug-micelle interaction and micellization process by light scattering and differential scanning calorimetry
(DSC), the sol-gel transition and hydrogel supramolecular structure by small-angle-X-ray scattering (SAXS)
andmorphological evaluation by Scanning ElectronMicroscopy (SEM). In addition,we have presented the investigation
of drug release mechanisms, in vitro/in vivo toxic and analgesic effects. Micellar dimensions evaluation
showed the formation of PL407-PL188 mixed micelles and the drug incorporation, as well as the DSC studies
showed increased enthalpy values for micelles formation after addition of PL 188 and RVC, indicating changes
on self-assembly and the mixed micelles formation evoked by drug incorporation. SAXS studies revealed that
the phase organization in hexagonal structure was not affected by RVC insertion into the hydrogels,maintaining
their supramolecular structure. SEManalysis showed similar patterns after RVC addition. The RVC release followed
the Higuchi model, modulated by the PL final concentration and the insertion of PL 188 into the system. Furthermore,
the association PL407-PL188 induced lower in vitro cytotoxic effects, increased the duration of
analgesia, in a single-dose model study, without evoking in vivo inflammation signs after local injection.
Como referenciar
AKKARI, ALESSANDRA C.S.; PAPINI, JULIANA Z.B.; GARCIA, GABRIELLA K.; FRANCO, MARGARETH K.K.D.; CAVALCANTI, LEIDE P.; GASPERINI, ANTONIO; ALKSCHBIRS, MELISSA I.; YOKAICHYIA, FABIANO; PAULA, ENEIDA de; TOFOLI, GIOVANA R.; ARAUJO, DANIELE R. de. Poloxamer 407/188 binary thermosensitive hydrogels as delivery systems for infiltrative local anesthesia: Physico-chemical characterization and pharmacological evaluation. Materials Science and Engineering C, v. 68, p. 299-307, 2016. DOI: 10.1016/j.msec.2016.05.088. Disponível em: http://repositorio.ipen.br/handle/123456789/27726. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.