New methodology for binding Iodine-125 onto silver for brachytherapy sources manufacture

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dc.contributor.authorSOUZA, C.D. dept_BR
dc.contributor.authorROSTELATO, M.C.M.pt_BR
dc.contributor.authorCARDOSO, R.M.pt_BR
dc.contributor.authorARAKI, K.pt_BR
dc.contributor.authorMOURA, J.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-04-27T14:54:25Z
dc.date.available2020-04-27T14:54:25Z
dc.date.issued2017pt_BR
dc.description.abstractPurpose: Cancer is a major health care problem in Brazil and the world. The Brazil’s National Institute for Cancer estimates around 60,000 new prostate cancer cases for 2017. We are assembling a laboratory for production of iodine-125 sources used in prostate brachytherapy in Brazil, since the imported treatment is extremely expensive, thus only available in the private healthcare sector. There are several challenges when developing a laboratory to produce radioactive sources. From choosing a prototype to radiation safety, the task is enormous. The whole production line is full of new process and innovations. Among those, a new chemical reaction that deposit iodine-125 onto silver (core) was developed. This paper presents a new reaction for binding iodine-125 into a silver core. The fixation percentage was calculated by measuring the activity in an ionization chamber. This methodology will be implemented at the iodine-125 sources manufacture laboratory. Methods: Silver cores are washed with an etching solution (100% sulfuric acid) for 5 minutes with sonication. The cores were then placed in sodium sulfate for at least 3 days. They went from a silver matte to a black color. The reaction was allowed to proceed overnight. Each core was individually measured. Results: The yield was 69.2% 7.1%. Considering the silver attenuation is around 20% the results were consider satisfactory. Conclusion: By maximize the reaction yield, we will be able to generate a less costly product that will be available through our public healthcare.pt_BR
dc.format.extent2828-2828pt_BR
dc.identifier.citationSOUZA, C.D. de; ROSTELATO, M.C.M.; CARDOSO, R.M.; ARAKI, K.; MOURA, J. New methodology for binding Iodine-125 onto silver for brachytherapy sources manufacture. <b>Medical Physics</b>, v. 44, n. 6, p. 2828-2828, 2017. DOI: <a href="https://dx.doi.org/10.1002/mp.12304">10.1002/mp.12304</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31136.
dc.identifier.doi10.1002/mp.12304pt_BR
dc.identifier.fasciculo6pt_BR
dc.identifier.issn0094-2405pt_BR
dc.identifier.orcid0000-0003-2943-6097pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5054-0799
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.orcidhttp://orcid.org/0000-0003-1335-8864
dc.identifier.percentilfi72.481pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31136
dc.identifier.vol44pt_BR
dc.relation.ispartofMedical Physicspt_BR
dc.rightsclosedAccesspt_BR
dc.sourceAnnual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine, 59th, July 30 - August 03, 2017, Denver, USApt_BR
dc.subjectbrachytherapy
dc.subjectiodine 125
dc.subjectsilver
dc.subjectneoplasms
dc.subjecttherapy
dc.titleNew methodology for binding Iodine-125 onto silver for brachytherapy sources manufacturept_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorJOÃO AUGUSTO MOURA
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.autorCARLA DARUICH DE SOUZA
ipen.codigoautor6611
ipen.codigoautor7
ipen.codigoautor7717
ipen.contributor.ipenauthorJOÃO AUGUSTO MOURA
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.contributor.ipenauthorCARLA DARUICH DE SOUZA
ipen.date.recebimento20-04
ipen.identifier.fi2.884pt_BR
ipen.identifier.ipendoc26914pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreResumo
relation.isAuthorOfPublication6a96a2fe-6eb6-488b-bd21-ac2b4e1335a3
relation.isAuthorOfPublicationda77b491-04ff-4c68-aa65-dead9208a48c
relation.isAuthorOfPublication866434dc-2634-4567-8b4b-04e5ce06bf04
relation.isAuthorOfPublication.latestForDiscovery866434dc-2634-4567-8b4b-04e5ce06bf04
sigepi.autor.atividadeMOURA, J.:6611:230:Npt_BR
sigepi.autor.atividadeROSTELATO, M.C.M.:7:230:Npt_BR
sigepi.autor.atividadeSOUZA, C.D. de:7717:230:Spt_BR
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