Poly(3-hydroxi-butyrate-co-3-hydroxy-valerate) (PHB-HV) microparticles loaded with holmium acetylacetonate as potential contrast agents for magnetic resonance images

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dc.contributor.authorAZEVEDO, MARIANGELA de B.M. dept_BR
dc.contributor.authorMELO, VITOR H.S.pt_BR
dc.contributor.authorSOARES, CARLOS R.J.pt_BR
dc.contributor.authorGAMARRA, LIONEL F.pt_BR
dc.contributor.authorBARROS, CAIO H.N.pt_BR
dc.contributor.authorTASIC, LJUBICApt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2019-12-19T14:20:31Z
dc.date.available2019-12-19T14:20:31Z
dc.date.issued2019pt_BR
dc.description.abstractIntroduction: Biodegradable polymers that contain radioactive isotopes such as Holmium 166 have potential applications as beta particle emitters in tumor tissues. Also, Ho(III) is paramagnetic, which makes it suitable as a contrast agent for magnetic resonance (MR) images. Methods: Holmium acetylacetonate (Ho(acac)3) loaded poly(3-hydroxy-butyrate-co-3- hydroxy-valerate) microspheres, with 5% or 8% of 3-hydroxy-valerate (HV), were prepared by emulsification/evaporation process within 20–53 μm size. Microspheres characterization was done using scanning electron microscopy, energy-dispersive X-ray, and infrared spectroscopies. The release of holmium(III) in sodium phosphate buffer (pH 7.4) was followed for 9 days with inductively coupled plasma. Finally, T2 and T2* magnetic resonance images (MRI) were acquired and compared with the MRI of the inclusion complex of holmium acetylacetonate in some β-cyclodextrins. Results: Holmium acetylacetonate loading, evaluated by thermogravimetry, was up to 20 times higher for copolymer with 5% of HV. It was shown that microspheres loaded with Ho(acac)3 exhibited an accumulation of Ho(III) on their surfaces but were stable over time, as no expressive release of holmium(III) was detected in 9-day exposition to sodium phosphate buffer. Holmium acetylacetonate in both microspheres or inclusion complexes was very efficient in obtaining T2 and T2* weighted images in magnetic resonance, thus, might be used as contrast agents. Conclusion: This is the first description of the use of inclusion complexes of holmium acetylacetonate in biodegradable polymers as contrast agents. New investigations are underway to evaluate the resistance of PHB-HV polymer microparticles to nuclear activation to assess their potential for use as radiopharmaceuticals for the treatment of liver cancer.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDCNPq: DT306980/2015-0; DT310247/2013-6; DT310227/2010-0; 560423/2010-1; 550598/2010-3; DT 315236/2018-3pt_BR
dc.description.sponsorshipIDFAPESP: 15/26058-0pt_BR
dc.format.extent6869-6889pt_BR
dc.identifier.citationAZEVEDO, MARIANGELA de B.M. de; MELO, VITOR H.S.; SOARES, CARLOS R.J.; GAMARRA, LIONEL F.; BARROS, CAIO H.N.; TASIC, LJUBICA. Poly(3-hydroxi-butyrate-co-3-hydroxy-valerate) (PHB-HV) microparticles loaded with holmium acetylacetonate as potential contrast agents for magnetic resonance images. <b>International Journal of Nanomedicine</b>, v. 14, p. 6869-6889, 2019. DOI: <a href="https://dx.doi.org/10.2147/IJN.S191274">10.2147/IJN.S191274</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/30466.
dc.identifier.doi10.2147/IJN.S191274pt_BR
dc.identifier.issn1178-2013pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7982-1789
dc.identifier.percentilfi79.871pt_BR
dc.identifier.percentilfiCiteScore85.67
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30466
dc.identifier.vol14pt_BR
dc.relation.ispartofInternational Journal of Nanomedicinept_BR
dc.rightsopenAccesspt_BR
dc.subjectpolymers
dc.subjectholmium
dc.subjectholmium 166
dc.subjectacetylacetone
dc.subjectcontrast media
dc.subjectmagnetic resonance
dc.subjectneoplasms
dc.subjecttherapy
dc.subjectmicrospheres
dc.titlePoly(3-hydroxi-butyrate-co-3-hydroxy-valerate) (PHB-HV) microparticles loaded with holmium acetylacetonate as potential contrast agents for magnetic resonance imagespt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorCARLOS ROBERTO JORGE SOARES
ipen.autorVITOR HUGO SOARES DE MELO
ipen.autorMARIANGELA DE BURGOS MARTINS DE AZEVEDO
ipen.codigoautor509
ipen.codigoautor10236
ipen.codigoautor8164
ipen.contributor.ipenauthorCARLOS ROBERTO JORGE SOARES
ipen.contributor.ipenauthorVITOR HUGO SOARES DE MELO
ipen.contributor.ipenauthorMARIANGELA DE BURGOS MARTINS DE AZEVEDO
ipen.date.recebimento19-12
ipen.identifier.fi5.115pt_BR
ipen.identifier.fiCiteScore7.1
ipen.identifier.ipendoc26487pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi4.500 - 5.999
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreArtigo
relation.isAuthorOfPublicationd6719ab2-f2e9-4d7c-9cea-a6316fc14c9e
relation.isAuthorOfPublicationd4789e43-7166-46db-b97d-ee8bb30c22e6
relation.isAuthorOfPublication75ddf36c-b3b8-4a19-94c8-620edfd9148e
relation.isAuthorOfPublication.latestForDiscovery75ddf36c-b3b8-4a19-94c8-620edfd9148e
sigepi.autor.atividadeSOARES, CARLOS R.J.:509:810:Npt_BR
sigepi.autor.atividadeMELO, VITOR H.S.:10236:-1:Npt_BR
sigepi.autor.atividadeAZEVEDO, MARIANGELA de B.M. de:8164:820:Spt_BR
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