Innovative burn treatment using tilapia skin as a xenograft
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Journal of Burn Care & Research
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Skin substitutes are considered a useful alternative for occlusive dressings in the treatment of superficial burns as
they reduce the frequency of dressing replacement. This phase II randomized controlled trial aimed to evaluate
the efficacy of Nile tilapia (Oreochromis niloticus) skin as an occlusive xenograft dressing for the treatment of burn
wounds in humans. In order to assess the use of tilapia skin, the following variables were evaluated: number of days
for wound healing, the number of times the occlusive dressing was changed, use of anesthetics or analgesics, pain
assessment using the Visual Analogue Scale, and evaluation of burn improvement on the day of dressing removal.
In total, 62 participants completed the study. It was found that in participants treated with tilapia skin, complete
reepithelialization occurred in significantly fewer days; reported pain intensity was lower (study arms B and C), the
amount of anesthetics/analgesics required was lower (study arms B and C), and the necessity of dressing changes
was significantly reduced in comparison with volunteers treated with silver sulfadiazine. In our study, the tilapia
skin xenograft showed good efficacy as an occlusive biological dressing for burn wound treatment in humans.
Como referenciar
LIMA JUNIOR, EDMAR M.; MORAES FILHO, MANOEL O. de; COSTA, BRUNO A.; ROHLEDER, ANDREA V.P.; ROCHA, MARINA B.S.; FECHINE, FRANCISCO V.; FORTE, ANTONIO J.; ALVES, ANA P.N.N.; SILVA JUNIOR, FRANCISCO R.; MARTINS, CAMILA B.; MATHOR, MONICA B.; MORAES, MARIA E.A. de. Innovative burn treatment using tilapia skin as a xenograft: a phase II randomized controlled trial. Journal of Burn Care & Research, v. 41, n. 3, p. 585-592, 2020. DOI: 10.1093/jbcr/irz205. Disponível em: http://repositorio.ipen.br/handle/123456789/31824. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.