Study of gamma-radiation effects on crotamine and crotoxin

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dc.contributor.authorCASARE, M.S.pt_BR
dc.contributor.authorSPENCER, P.pt_BR
dc.contributor.authorCAMPOS, L.A.pt_BR
dc.contributor.authorNASCIMENTO, N.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-15T13:47:53Zpt_BR
dc.date.accessioned2014-07-30T11:51:25Z
dc.date.available2014-07-15T13:47:53Zpt_BR
dc.date.available2014-07-30T11:51:25Z
dc.date.issued2006pt_BR
dc.description.abstractCrotoxin is a 23 kDa neurotoxin from Crotalus durissus terrificus and is composed of a 9 kDa acidic subunit (crotapotin) and a 14 kDa basic subunit (phospholipase A2). Crotamine is 4882 Da, basic polypeptide with myotoxic activity. These toxins, when submitted to gamma-rays, in aqueous solution, present structural modifications, preserving their immunogenic properties. In the present work, we investigated some structural modifications on both crotoxin and crotamine after gamma-radiation using various doses, in the presence or not of "scavenger" substances. Our results indicate that irradiation leads to progressive changes in the structure of the toxin, which could explain the lower toxicity observed.
dc.format.extent571-577pt_BR
dc.identifier.citationCASARE, M.S.; SPENCER, P.; CAMPOS, L.A.; NASCIMENTO, N. Study of gamma-radiation effects on crotamine and crotoxin. <b>Journal of Radioanalytical and Nuclear Chemistry</b>, v. 269, n. 3, p. 571-577, 2006. DOI: <a href="https://dx.doi.org/10.1007/s10967-006-0267-6">10.1007/s10967-006-0267-6</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/5414.
dc.identifier.doi10.1007/s10967-006-0267-6
dc.identifier.fasciculo3pt_BR
dc.identifier.issn0236-5731pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8949-7735
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/5414pt_BR
dc.identifier.vol269pt_BR
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistrypt_BR
dc.rightsopenAccessen
dc.subjectvenomspt_BR
dc.subjectsnakespt_BR
dc.subjectgamma radiationpt_BR
dc.subjectcobalt 60pt_BR
dc.subjectmolecular structurept_BR
dc.subjectradiation effectspt_BR
dc.subjectnerve cellspt_BR
dc.subjectproteinspt_BR
dc.subjectstructural chemical analysispt_BR
dc.subjecttoxinspt_BR
dc.titleStudy of gamma-radiation effects on crotamine and crotoxinpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorNANCI DO NASCIMENTO
ipen.autorLUCELIA DE ALMEIDA CAMPOS
ipen.autorPATRICK JACK SPENCER
ipen.autorMURILO CASARE DA SILVA
ipen.codigoautor411
ipen.codigoautor3033
ipen.codigoautor910
ipen.codigoautor2566
ipen.contributor.ipenauthorNANCI DO NASCIMENTO
ipen.contributor.ipenauthorLUCELIA DE ALMEIDA CAMPOS
ipen.contributor.ipenauthorPATRICK JACK SPENCER
ipen.contributor.ipenauthorMURILO CASARE DA SILVA
ipen.date.recebimento07-03pt_BR
ipen.identifier.fi0.509pt_BR
ipen.identifier.ipendoc11621pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi0.001 - 1.499
ipen.type.genreArtigo
relation.isAuthorOfPublication53eed426-0bd7-4230-8b8c-f48795fad345
relation.isAuthorOfPublication8f3cc76e-9ae1-4a5c-aba8-71459f5ba55a
relation.isAuthorOfPublication4eb7939e-aeea-4991-8525-b3d05ac27364
relation.isAuthorOfPublication6ed94a58-5ab4-406b-b91b-d42bd90131aa
relation.isAuthorOfPublication.latestForDiscovery6ed94a58-5ab4-406b-b91b-d42bd90131aa
sigepi.autor.atividadeCASARE, M.S.:2566:19:Spt_BR
sigepi.autor.atividadeSPENCER, P.:910:19:Npt_BR
sigepi.autor.atividadeCAMPOS, L.A.:3033:19:Npt_BR
sigepi.autor.atividadeNASCIMENTO, N.:411:19:Npt_BR
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