Compartmental and dosimetric studies of anti-CD20 labeled with sup(188)Re

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dc.contributor.advisor
dc.contributor.authorKURAMOTO, GRACIELA BARRIO
dc.contributor.authorMATSUDA, MARGARETH M.N.
dc.contributor.authorOSSO JUNIOR, JOAO A.
dc.coverageInternacionalpt_BR
dc.date.accessioned2016-08-03T12:45:32Z
dc.date.available2016-08-03T12:45:32Z
dc.date.issued2016pt_BR
dc.description.abstractRadioimmunotherapy has the potential to deliver lethal radiation energy directly to malignant cells via targeting of radioisotope-conjugated monoclonal antibodies (MAbs) to specific antigens. Rituximab (RTX) is specifically targeted against CD20, a surface antigen expressed by B-lymphocytes. The use of 188Re from a 188W/188Re generator system represents an alternative radionuclide for therapy. Rhenium has chemical properties similar to technetium and both can be conjugated to antibodies using similar chemistry methods. The objective of this work is to prove the usefulness of this radiopharmaceutical based on dosimetric and pharmacokinetic studies that are also required by the Brazilian Regulatory Agency.
dc.format.extent1029-1035pt_BR
dc.identifier.citationKURAMOTO, GRACIELA BARRIO; MATSUDA, MARGARETH M.N.; OSSO JUNIOR, JOAO A. Compartmental and dosimetric studies of anti-CD20 labeled with sup(188)Re. <b>Journal of Radioanalytical and Nuclear Chemistry</b>, v. 309, n. 3, p. 1029-1035, 2016. DOI: <a href="https://dx.doi.org/10.1007/s10967-016-4703-y">10.1007/s10967-016-4703-y</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/26526.
dc.identifier.doi10.1007/s10967-016-4703-y
dc.identifier.fasciculo3pt_BR
dc.identifier.issn0236-5731pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6672-1631
dc.identifier.orcidhttps://orcid.org/0000-0003-4455-3486
dc.identifier.percentilfi43.10
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/26526
dc.identifier.vol309pt_BR
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistrypt_BR
dc.rightsopenAccesspt_BR
dc.subjecttherapy
dc.subjectlymphomas
dc.subjectrhenium 188
dc.subjectdosimetry
dc.subjectlabelled compounds
dc.subjectlymphocytes
dc.subjectradiopharmaceuticals
dc.subjectpharmacology
dc.subjectantibodies
dc.titleCompartmental and dosimetric studies of anti-CD20 labeled with sup(188)Rept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorJOAO ALBERTO OSSO JUNIOR
ipen.autorMARGARETH MIE NAKAMURA MATSUDA
ipen.autorGRACIELA BARRIO KURAMOTO
ipen.codigoautor140
ipen.codigoautor841
ipen.codigoautor3495
ipen.contributor.ipenauthorJOAO ALBERTO OSSO JUNIOR
ipen.contributor.ipenauthorMARGARETH MIE NAKAMURA MATSUDA
ipen.contributor.ipenauthorGRACIELA BARRIO KURAMOTO
ipen.date.recebimento16-08pt_BR
ipen.identifier.fi1.282pt_BR
ipen.identifier.ipendoc22432pt_BR
ipen.identifier.ods3
ipen.range.fi0.001 - 1.499
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublicationb0d5c854-8fcb-4e5f-b1c9-73e82c9ca844
relation.isAuthorOfPublicationfa01cabc-d76d-45ee-bb21-4994c14ba167
relation.isAuthorOfPublication612cad3f-6da1-4666-bf9b-4e207863f2d5
relation.isAuthorOfPublication.latestForDiscovery612cad3f-6da1-4666-bf9b-4e207863f2d5
sigepi.autor.atividadeKURAMOTO, GRACIELA BARRIO:3495:110:S
sigepi.autor.atividadeMATSUDA, MARGARETH M.N.:841:110:N
sigepi.autor.atividadeOSSO JUNIOR, JOAO A.:140:-1:N
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