Chlorhexidine loaded MMT as dental composite filler: release evaluation
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Polymeric restorative materials are widely used, however polymerization shrinkage still
stands as a major drawback as it allows microleakage, secondary caries, postoperative sensitivity
and cusp deflection. A polymeric material with antimicrobial activity could be very
useful in many dental procedures including adhesive cementation, sealants, dental adhesives
and direct restorative material. The aim of this study was to develop nanocomposites
for dental purposes composed by chlorhexidine loaded montmorillonite (Cloisite 30B) nanoparticles
in a BisGMA / TEGDMA organic matrix. The specimens of experimental
composites were synthesized with 10 % (w/w) of diacetate chlorhexidine incorporated in a
MMT, as filler. The chlorhexidine release at 37 oC was evaluated in vitro in physiological
solution at neutral pH for 366 hours. Drug content was estimated by UV spectroscopy at
λ=255 nm. Significant drug release initiated after 96 hours and maintained throughout the
experiment. In conclusion, the composite was capable of promoting chlorhexidine release
over time, and such results in addition to the lack of significant weight loss (≤ 1.43 %) and
the very low swelling (≤ 2.22 %) properties, revealed the strong potential of the developed
composite for further dental and other biomaterial applications.
Como referenciar
CAMPOS, LUIZA; BOARO, LETICIA; SANTOS, TAMIRIS; SANTOS, VINICIUS; VARCA, GUSTAVO; PARRA, DUCLERC. Chlorhexidine loaded MMT as dental composite filler: release evaluation. Revista Matéria, v. 00, n. 0, 2013. Disponível em: http://repositorio.ipen.br/handle/123456789/27382. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.