Membrane-translocating peptides and toxins
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Journal of the Brazilian Chemical Society
Exportar
Resumo
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for molecular design of improved derivatives. Here, we refer to members of three classes of remarkable peptides and toxins that act at the cell membranes level and membrane trafficking systems: (i) the binary toxins (ii) the antimicrobial peptides and (iii) the cell penetrating peptides. Binary toxins have been genetically manipulated to generate specific immunotoxins, while antimicrobial peptides are in use as alternative agents against resistant microbes and tumor cells. Cell penetrating peptides have applications as diverse as cell transfection and transport of nanomaterials. Our group is dissecting the capacity of crotamine, a peptide from rattlesnake venom, to translocate cell membranes and use it as a delivery system in the transducing technology and molecular imaging.
Como referenciar
RADIS-BAPTISTA, GANDHI; KERKIS, ALEXANDRE; PRIETO-SILVA, ALVARO R.; HAYASHI, MIRIAN A.F.; KERKIS, IRINA; YAMANE, TETSUO. Membrane-translocating peptides and toxins: from nature to bedside. Journal of the Brazilian Chemical Society, v. 19, n. 2, p. 211-225, 2008. DOI: 10.1590/S0103-50532008000200004. Disponível em: http://repositorio.ipen.br/handle/123456789/7889. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.