Apoptosis through Bcl-2/Bax and cleaved caspase Up-regulation in melanoma treated by boron neutron capture therapy
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Boron neutron capture therapy (BNCT) is a binary treatment involving selective accumulation of boron carriers in a tumor
followed by irradiation with a thermal or epithermal neutron beam. The neutron capture reaction with a boron-10 nucleus
yields high linear energy transfer (LET) particles, alpha and 7
Li, with a range of 5 to 9 mm. These particles can only travel very
short distances and release their damaging energy directly into the cells containing the boron compound. We aimed to
evaluate proliferation, apoptosis and extracellular matrix (ECM) modifications of B16F10 melanoma and normal human
melanocytes after BNCT. The amounts of soluble collagen and Hsp47, indicating collagen synthesis in the ECM, as well as
the cellular markers of apoptosis, were investigated. BNCT decreased proliferation, altered the ECM by decreasing collagen
synthesis and induced apoptosis by regulating Bcl-2/Bax in melanoma. Additionally, BNCT also increased the levels of TNF
receptor and the cleaved caspases 3, 7, 8 and 9 in melanoma. These results suggest that multiple pathways related to cell
death and cell cycle arrest are involved in the treatment of melanoma by BNCT.
Como referenciar
FAIAO FLORES, FERNANDA; COELHO, PAULO R.P.; ARRUDA NETO, JOAO D.T.; MARIA ENGLER, SILVYA S.; TIAGO, MANOELA; CAPELOZZI, VERA L.; GIOGI, RICARDO R.; MARIA, DURVANEI A. Apoptosis through Bcl-2/Bax and cleaved caspase Up-regulation in melanoma treated by boron neutron capture therapy. PLoS ONE, v. 8, n. 3, 2013. DOI: 10.1371/journal.pone.0059639. Disponível em: http://repositorio.ipen.br/handle/123456789/8466. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.