Photodynamic therapy on feline squamous cell carcinoma with methyl 5-aminolevulinate
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2007
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REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE BIOQUIMICA E BIOLOGIA MOLECULAR, 34.
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Resumo
Photodynamic therapy of tumors with various photosensitizers, including
porphyrins and 5-aminolevulinic acid (ALA) derivatives, has been widely used. We
study here the efficacy of methyl 5-aminolevulinate (ALAME) formulated with
dimethylenetriaminepentaacetic acid (DTPA) in the treatment of feline squamous
cell carcinoma (FSCC) that usually occurs in unpigmented cats UV-exposed
chronically. Eight cats with FSCC were selected for this study. The sensitizer was
applied topically on the tumor during four hours. Then, an array of 30 light emitting
diodes was used to irradiate the lesion (light dose = 12 J/cm2
). Results were
clinically qualified as “complete response” (total disappearance of the crusting
lesion with re-epithelisation to healthy skin), “partial response” (>50% reduction in
tumor size) and “no response”. Biopsies were performed on the site of lesion after
five months of treatment. Three cats had complete response and five, partial
response, evaluated by histological analyses. In conclusion, ALAME/DTPA
photodynamic therapy constitutes a possible choice in the treatment of FSCC.
Como referenciar
EMILIO, C.R.; BECHARA, E.J.H.; DAGLI, M.L.Z.; DUTRA, F.; GIOSO, M.A.; PINOTTI, M.; ZEZELL, D.M. Photodynamic therapy on feline squamous cell carcinoma with methyl 5-aminolevulinate. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE BIOQUIMICA E BIOLOGIA MOLECULAR, 34., 21-25 de maio, 2007, Salvador, BA. Resumo... Disponível em: http://repositorio.ipen.br/handle/123456789/22824. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.