Anti-MUC1 nano-aptamers for triple-negative breast cancer imaging by single-photon emission computed tomography in inducted animals: initial considerations
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International Journal of Nanomedicine
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The early and specific detection of tumors remains a barrier in oncology, especially in cases such as the triple-negative breast cancer (TNBC). To address this gap, aptamers have found an important application in the recognition of tumor biomarkers such as mucin 1 (MUC1). However, there are still some difficulties in the use of aptamer, as their rapid biological clearance makes their use as drugs limited. In this study, the anti-MUC1 aptamer was used as a drug delivery system (DDS) for a radioactive polymeric nanoparticle (NP) in the imaging of TNBCs. Thus, poly(lactic-co-glycolic acid) NPs loaded with the anti-MUC1 aptamer and labeled with technetium-99m were used for a biodistribution study and imaging of TNBC. The results confirmed that the NP was successfully obtained, with a mean size of 262 nm, according to the dynamic light scattering data. The biodistribution assay in induced animal models with TNBC showed that although there was a high capture by intestine (>30%), the DDS developed had a high tumor uptake (5%) and with great in vivo imaging properties, corroborating the possibility of use of this DDS as an imaging drug for TNBC.
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CARMO, FAGNER S. do; RICCI-JUNIOR, EDUARDO; CERQUEIRA-COUTINHO, CRISTAL; ALBERNAZ, MARTA de S.; BERNARDES, EMERSON S.; MISSAILIDIS, SOTIRIS; SANTOS-OLIVEIRA, RALPH. Anti-MUC1 nano-aptamers for triple-negative breast cancer imaging by single-photon emission computed tomography in inducted animals: initial considerations. International Journal of Nanomedicine, v. 12, p. 53-60, 2017. DOI: 10.2147/IJN.S118482. Disponível em: http://repositorio.ipen.br/handle/123456789/27848. Acesso em: 30 Dec 2025.
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