Development of glycan‑targeted nanoparticles as a novel therapeutic opportunity for gastric cancer treatment

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dc.contributor.authorSANTOS, SOFIA N. dospt_BR
dc.contributor.authorGUSHIKEN JUNIOR, DINO S.pt_BR
dc.contributor.authorPEREIRA, JHONATAS P.M.pt_BR
dc.contributor.authorIADOCICCO, NATALIA M.pt_BR
dc.contributor.authorSILVA, ANDRE H.pt_BR
dc.contributor.authorNASCIMENTO, TATIELLE dopt_BR
dc.contributor.authorDIAS, LUIS A.P.pt_BR
dc.contributor.authorSILVA, FLAVIA R. de O.pt_BR
dc.contributor.authorRICCI-JUNIOR, EDUARDOpt_BR
dc.contributor.authorSANTOS-OLIVEIRA, RALPHpt_BR
dc.contributor.authorBERNARDES, EMERSON S.pt_BR
dc.coverageInternacional
dc.date.accessioned2023-04-26T19:25:45Z
dc.date.available2023-04-26T19:25:45Z
dc.date.issued2023pt_BR
dc.description.abstractChemotherapy resistance remains a major cause of therapeutic failure in gastric cancer. The combination of genetic material such as interference RNAs (iRNAs) to silence cancer-associated genes with chemotherapeutics has become a novel approach for cancer treatment. However, finding the right target genes and developing non-toxic, highly selective nanocarrier systems remains a challenge. Here we developed a novel sialyl-Tn-targeted polylactic acid—didodecyldimethylammonium bromide nanoparticle (PLA-DDAB) nanoparticles (NPs) loaded with dsRNA targeting ST6GalNac-I and/or galectin-3 genes. Using single photon emission computed tomography (SPECT), we have demonstrated that 99mtechnetium radiolabeled sialyl-Tn-targeted nanoparticles can reach the tumor site and downregulate ST6GalNAc-I and galectin-3 RNA expression levels when injected intravenously. Furthermore, using an in vivo gastric tumor model, these nanoparticles increased the effectiveness of 5-FU in reducing tumor growth. Our findings indicate that cancer-associated glycan-targeted NPs loaded with dsRNA targeting ST6GalNAc-I and/or galectin-3 in combination with standard chemotherapy, have the potential to become a novel therapeutic tool for gastric cancer.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)pt_BR
dc.description.sponsorshipIDFAPESP: 12/06875-6pt_BR
dc.description.sponsorshipIDCNPq: 300376/2017-0pt_BR
dc.description.sponsorshipIDFAPERJ: E-26/200.815/2021; E-26/010.000981/2019pt_BR
dc.format.extent1-21pt_BR
dc.identifier.citationSANTOS, SOFIA N. dos; GUSHIKEN JUNIOR, DINO S.; PEREIRA, JHONATAS P.M.; IADOCICCO, NATALIA M.; SILVA, ANDRE H.; NASCIMENTO, TATIELLE do; DIAS, LUIS A.P.; SILVA, FLAVIA R. de O.; RICCI-JUNIOR, EDUARDO; SANTOS-OLIVEIRA, RALPH; BERNARDES, EMERSON S. Development of glycan‑targeted nanoparticles as a novel therapeutic opportunity for gastric cancer treatment. <b>Cancer Nanotechnology</b>, v. 14, n. 1, p. 1-21, 2023. DOI: <a href="https://dx.doi.org/10.1186/s12645-023-00161-2">10.1186/s12645-023-00161-2</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/34015.
dc.identifier.doi10.1186/s12645-023-00161-2pt_BR
dc.identifier.fasciculo1pt_BR
dc.identifier.issn1868-6958
dc.identifier.orcid0000-0002-0029-7313pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0029-7313
dc.identifier.percentilfi66.4
dc.identifier.percentilfiCiteScore59.75
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/34015
dc.identifier.vol14pt_BR
dc.relation.ispartofCancer Nanotechnology
dc.rightsopenAccesspt_BR
dc.subjectneoplasms
dc.subjectstomach
dc.subjectrna
dc.subjectantigens
dc.subjectchemotherapy
dc.titleDevelopment of glycan‑targeted nanoparticles as a novel therapeutic opportunity for gastric cancer treatmentpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDINO SEIGO GUSHIKEN JUNIOR
ipen.autorNATALIA MIRANDA IADOCICCO
ipen.autorFLAVIA RODRIGUES DE OLIVEIRA SILVA
ipen.autorEMERSON SOARES BERNARDES
ipen.autorLUIS ALBERTO PEREIRA DIAS
ipen.autorANDRE HENRIQUE SILVA
ipen.autorJHONATAS PEDROSA MARIM PEREIRA
ipen.autorSOFIA NASCIMENTO DOS SANTOS
ipen.codigoautor15448
ipen.codigoautor15888
ipen.codigoautor5910
ipen.codigoautor12099
ipen.codigoautor796
ipen.codigoautor15468
ipen.codigoautor15034
ipen.codigoautor14464
ipen.contributor.ipenauthorDINO SEIGO GUSHIKEN JUNIOR
ipen.contributor.ipenauthorNATALIA MIRANDA IADOCICCO
ipen.contributor.ipenauthorFLAVIA RODRIGUES DE OLIVEIRA SILVA
ipen.contributor.ipenauthorEMERSON SOARES BERNARDES
ipen.contributor.ipenauthorLUIS ALBERTO PEREIRA DIAS
ipen.contributor.ipenauthorANDRE HENRIQUE SILVA
ipen.contributor.ipenauthorJHONATAS PEDROSA MARIM PEREIRA
ipen.contributor.ipenauthorSOFIA NASCIMENTO DOS SANTOS
ipen.date.recebimento23-04
ipen.identifier.fi4.5
ipen.identifier.fiCiteScore5.2
ipen.identifier.ipendoc29639
ipen.identifier.iwosWoSpt_BR
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ipen.type.genreArtigo
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sigepi.autor.atividadeBERNARDES, EMERSON S.:12099:110:Npt_BR
sigepi.autor.atividadeSILVA, FLAVIA R. de O.:5910:810:Npt_BR
sigepi.autor.atividadeDIAS, LUIS A.P.:796:120:Npt_BR
sigepi.autor.atividadeSILVA, ANDRE H.:15468:110:Npt_BR
sigepi.autor.atividadeIADOCICCO, NATALIA M.:15888:-1:Npt_BR
sigepi.autor.atividadePEREIRA, JHONATAS P.M.:15034:110:Npt_BR
sigepi.autor.atividadeGUSHIKEN JUNIOR, DINO S.:15448:-1:Npt_BR
sigepi.autor.atividadeSANTOS, SOFIA N. dos:14464:110:Spt_BR
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