Plant-derived polyphenolic compounds
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Critical Reviews in Food Science and Nutrition
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Plant-derived polyphenols are naturally occurring compounds widely distributed in plants. They
have received greater attention in the food and pharmaceutical industries due to their potential
health benefits, reducing the risk of some chronic diseases due to their antioxidant, anti-inflammatory,
anticancer, cardioprotective, and neuro-action properties. Polyphenolic compounds orally
administered can be used as adjuvants in several treatments but with restricted uses due to
chemical instability. The review discusses the different structural compositions of polyphenols and
their influence on chemical stability. Despite the potential and wide applications, there is a need to
improve the delivery of polyphenolics to target the human intestine without massive chemical
modifications. Oral administration of polyphenols is unfeasible due to instability, low bioaccessibility,
and limited bioavailability. Nano-delivery systems based on polysaccharides (starch, pectin, chitosan,
and cellulose) have been identified as a viable option for oral ingestion, potentiate biological effects,
and direct-controlled delivery in specific tissues. The time and dose can be individualized for specific
diseases, such as intestinal cancer. This review will address the mechanisms by which
polysaccharides-based nanostructured systems can protect against degradation and enhance
intestinal permeation, oral bioavailability, and the potential application of polysaccharides as
nanocarriers for the controlled and targeted delivery of polyphenolic compounds.
Como referenciar
ROSALES, THIECLA K.O.; SILVA, FABIO F.A. da; BERNARDES, EMERSON S.; FABI, JOAO P. Plant-derived polyphenolic compounds: nanodelivery through polysaccharidebased systems to improve the biological properties. Critical Reviews in Food Science and Nutrition, p. 1-25, 2023. DOI: 10.1080/10408398.2023.2245038. Disponível em: http://repositorio.ipen.br/handle/123456789/34394. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.