Macroscopic self-organized electrochemical patterns in excitable tissue and irreversible thermodynamics
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Open Journal of Biophysics
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In this paper we make the assertion that the key to understand the emergent properties
of excitable tissue (brain and heart) lies in the application of irreversible thermodynamics.
We support this assertion by pointing out where symmetry break,
phase transitions both in structure of membranes as well as in the dynamic of interactions
between membranes occur in excitable tissue and how they create emergent
low dimensional electrochemical patterns. These patterns are expressed as physiological
or physiopathological concomitants of the organ or organism behavior. We
propose that a set of beliefs about the nature of biological membranes and their interactions
are hampering progress in the physiology of excitable tissue. We will argue
that while there is no direct evidence to justify the belief that quantum mechanics has
anything to do with macroscopic patterns expressed in excitable tissue, there is plenty
of evidence in favor of irreversible thermodynamics. Some key predictions have
been fulfilled long time ago and they have been ignored by the mainstream literature.
Dissipative structures and phase transitions appear to be a better conceptual context
to discuss biological self-organization. The central role of time as a global coupling
agent is emphasized in the interpretation of the presented results.
Como referenciar
LIMA, VERA M.F. de; HANKE, WOLFGANG. Macroscopic self-organized electrochemical patterns in excitable tissue and irreversible thermodynamics. Open Journal of Biophysics, v. 6, p. 98-124, 2016. DOI: 10.4236/ojbiphy.2016.64011. Disponível em: http://repositorio.ipen.br/handle/123456789/27145. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.