Comparative study of cl determination in antilonomic serum for caterpillars lonomia obliqua walker using EDXRF

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dc.contributor.authorSIMONS, SIMONE M.
dc.contributor.authorLEAO, ANICARINE R.
dc.contributor.authorWEN, FAN H.
dc.contributor.authorZAMBONI, CIBELE B.
dc.coverageInternacionalpt_BR
dc.creator.eventoRIO SYMPOSIUM ON ATOMIC SPECTROMETRY, 14thpt_BR
dc.date.accessioned2017-07-10T16:03:12Z
dc.date.available2017-07-10T16:03:12Z
dc.date.evento02-07 de abril, 2017pt_BR
dc.description.abstractThe caterpillars Lonomia obliqua Walker (L. obliqua) species is very poisonous and has the ability to cause serious and fatal hemorrhagic effects in humans after contact [1]. The Butantan Institute (Research Center, São Paulo city) produces antilonomic serum (antidote), to reverse such effects, using caterpillars mainly from Paraná (PR) where the prevalence of incidents is high. However, in the last year, this species has present in various regions (Santa Catarina, São Paulo and Rio Grande do Sul) from Brazil and there is no data of its elemental composition to ensure that the antivenom produced (considering the different origins) may be used to manufacture serum unchanged in the final product. Recent measurements identified mainly Cl was majority [2]. In this investigation, we intend to check the Cl range of the antigen obtained from Parana (standardize the antigen) using EDXRF. The XRF measurements were performed using MINI X-ray spectrometer (PXRFS) from Amptek (Bedford, MA, USA) model X-123 SDD with Ag X-ray tube. The characteristics X-ray fluorescent intensity of Cl was measured with a Si detector (Si Drift 25 mm2 x 500 μm/ 0.5 mil. The excitation was performed using 30 kV and 5 μA excitation for a counting time of 100s. The quantitative analysis was performed using WinQxas software program (IAEA, version 1.3). A comparison using data from Neutron Activation Analysis emphasizes a good agreement, suggesting the viability of using the compact spectrometer to monitor the antigens from different origins in fast and efficient way. These data can be used to standardize a specific antilonomic serum for caterpillars (L. obliqua) coming from different regions of Brazil, based in Cl range, which reduce cost in the serum production process, meeting the standards of good manufacturing practices and good laboratory practice.pt_BR
dc.identifier.citationSIMONS, SIMONE M.; LEAO, ANICARINE R.; WEN, FAN H.; ZAMBONI, CIBELE B. Comparative study of cl determination in antilonomic serum for caterpillars lonomia obliqua walker using EDXRF. In: RIO SYMPOSIUM ON ATOMIC SPECTROMETRY, 14th, 02-07 de abril, 2017, Vitória, ES. <b>Abstract...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/27661.
dc.identifier.orcidhttps://orcid.org/0000-0001-7766-2692
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27661
dc.local.eventoVitória, ESpt_BR
dc.rightsopenAccesspt_BR
dc.titleComparative study of cl determination in antilonomic serum for caterpillars lonomia obliqua walker using EDXRFpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorCIBELE BUGNO ZAMBONI
ipen.autorANICARINE RIBEIRO LEAO
ipen.codigoautor267
ipen.codigoautor15238
ipen.contributor.ipenauthorCIBELE BUGNO ZAMBONI
ipen.contributor.ipenauthorANICARINE RIBEIRO LEAO
ipen.date.recebimento17-07pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc23904pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication563d95e5-227e-456d-a1d7-4bb051ae51ba
relation.isAuthorOfPublication2f9adfbd-8a3e-4d06-9250-43f780b661d9
relation.isAuthorOfPublication.latestForDiscovery2f9adfbd-8a3e-4d06-9250-43f780b661d9
sigepi.autor.atividadeZAMBONI, CIBELE B.:267:310:Npt_BR
sigepi.autor.atividadeLEAO, ANICARINE R.:15238:-1:N
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