Kinetics of elimination and distribution in blood and liver of biocompartible ferrofluids base on Fesub(3)Osub(4) nanoparticles: An EPR and XRF study
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Materials Science and Engineering, C
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In this study, we evaluated the biodistribution and the elimination kinetics of a biocompatible magnetic fluid, Endorem™, based on dextrancoated Fe3O4 nanoparticles endovenously injected into Winstar rats. The iron content in blood and liver samples was recorded using electron
paramagnetic resonance (EPR) and X-ray fluorescence (XRF) techniques. The EPR line intensity at g= 2.1 was found to be proportional to the
concentration of magnetic nanoparticles and the best temperature for spectra acquisition was 298 K. Both EPR and XRF analysis indicated that the
maximum concentration of iron in the liver occurred 95 min after the ferrofluid administration. The half-life of the magnetic nanoparticles (MNP) in
the blood was (11.6 ± 0.6) min measured by EPR and (12.6 ± 0.6) min determined by XRF. These results indicate that both EPR and XRF are very
useful and appropriate techniques for the study of kinetics of ferrofluid elimination and biodistribution after its administration into the organism.
Como referenciar
GAMARRA, L.F.; PONTUSCHKA, W.M.; AMARO JUNIOR, E.; COSTA FILHO, A.J.; BRITO, G.E.S.; VIEIRA, E.D.; CARNEIRO, S.M.; ESCRIBA, D.M.; FALLEIROS, A.M.F.; SALVADOR, V.L. Kinetics of elimination and distribution in blood and liver of biocompartible ferrofluids base on Fesub(3)Osub(4) nanoparticles: An EPR and XRF study. Materials Science and Engineering, C, v. 28, p. 519-525, 2008. Disponível em: http://repositorio.ipen.br/handle/123456789/7900. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.