Use of pseudoboehmite for drug delivery system of simvastatin

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dc.contributor.authorVICENTE, MARCOS A.A.H.pt_BR
dc.contributor.authorMUNHOZ JUNIOR, ANTONIO H.pt_BR
dc.contributor.authorMIRANDA, LEILA F. dept_BR
dc.contributor.authorSARMENTO, BRUNO F.C.C.pt_BR
dc.contributor.authorBERNUSSI, AYRTONpt_BR
dc.contributor.authorOLIVEIRA, RENEpt_BR
dc.contributor.authorRIBEIRO, ROBERTO R.pt_BR
dc.contributor.authorMORAES, DENISON A.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoBRAZIL MRS MEETING, 18thpt_BR
dc.date.accessioned2020-04-02T16:31:57Z
dc.date.available2020-04-02T16:31:57Z
dc.date.eventoSeptember 22-26, 2019pt_BR
dc.description.abstractSimvastatin is a well known anti-cholesterol drug that is commercially available in Brazil in various strengths including Simvastatin Tablets, with 10, 20 and 40 mg. Simvastatin is a drug, which is used for treating patients with hypercholesterolemia, in order to prevent atherosclerosis, cardiovascular disease, and stroke1. Today cardiovascular disease is still the leading cause of death worldwide. It should also be noted that the treatment of cardiovascular diseases was responsible for just over a third of what the Brazilian federal government disbursed between the years 2013 and 2016 in the purchase of medicines for the population. However, the side effects of simvastatin include muscle pain and liver problems. When diet and exercise are not enough to reduce cholesterol levels, drugs as simvastatin are the medication prescribed. One problem of simvastatin is the low solubility. Simvastatin is practically insoluble in water (30 μg/mL), and 0.1 M HCl (60 μg/mL) [1,2,3]. This paper presents pseudoboehmite nanoparticles synthesized via sol-gel process. The pseudoboehmite were synthesized by an ethanol/water sol–gel method using aluminum nitrate as precursos and sodium hydroxide. The pseudoboehmite with simvastatin entrapped was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) using secondary electrons detector and EDS detector, thermal analysis (thermogravimetric analysis and differential thermal analysis) and Fourier transform infrared spectrometer (FTIR). The data shows that the simvastatin was incorporated homogenously in the pseudoboehmite. The Fourier transform infrared analysis shows that there was no degradation of the drug.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 10/19157-9; 17/22396-4pt_BR
dc.event.siglaB-MRSpt_BR
dc.format.extent687-688pt_BR
dc.identifier.citationVICENTE, MARCOS A.A.H.; MUNHOZ JUNIOR, ANTONIO H.; MIRANDA, LEILA F. de; SARMENTO, BRUNO F.C.C.; BERNUSSI, AYRTON; OLIVEIRA, RENE; RIBEIRO, ROBERTO R.; MORAES, DENISON A. Use of pseudoboehmite for drug delivery system of simvastatin. In: BRAZIL MRS MEETING, 18th, September 22-26, 2019, Balneário Camburiú, SC. <b>Abstract...</b> São Carlos, SP: Aptor Software, 2019. p. 687-688. Disponível em: http://repositorio.ipen.br/handle/123456789/31053.
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31053
dc.localSão Carlos, SPpt_BR
dc.local.eventoBalneário Camburiú, SCpt_BR
dc.publisherAptor Softwarept_BR
dc.rightsopenAccesspt_BR
dc.titleUse of pseudoboehmite for drug delivery system of simvastatinpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorRENE RAMOS DE OLIVEIRA
ipen.codigoautor942
ipen.contributor.ipenauthorRENE RAMOS DE OLIVEIRA
ipen.date.recebimento20-04
ipen.event.datapadronizada2019pt_BR
ipen.identifier.ipendoc26843pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublicationb56dc8d5-99b9-470b-a66d-098efd4f7939
relation.isAuthorOfPublication.latestForDiscoveryb56dc8d5-99b9-470b-a66d-098efd4f7939
sigepi.autor.atividadeOLIVEIRA, RENE:942:730:Npt_BR
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