Photodynamic Therapy to destroy pneumonia associated microorganisms using external irradiation source
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2018
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LIGHT-BASED DIAGNOSIS AND TREATMENT OF INFECTIOUS DISEASES
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An endotracheal tube (ETT) is required for the management of critically ill, mechanically ventilated patients. Ventilatorassociated
pneumonia (VAP) affects patients hospitalized in intensive care units; its risk of occurrence is 1% to up 3%
for each day of mechanical ventilation. The polymicrobial nature of VAP is established with mixed bacterial-fungal
biofilms colonizing the ETT. The microbial interaction enhances the microbial pathogenesis contributing to high indexes
of morbidity/mortality. Antimicrobial Photodynamic Therapy (aPDT) could be a suitable therapy for decontamination of
oral cavity and ETT at the same time, but the use of a fiber optics inside the ETT seems to not be appropriated since a
cannula for secretion aspiration has to be introduced into the ETT to keep it´s lumen. The aim of this study is to proof the
concept that an external light source from a LED is capable of reach all areas of the ETT. We use a commercial ETT,
60μM methylene blue (MB), and a 660nm diode laser and calculated the transmission coefficient of light in different
situations as only tube, tube with biofilm and biofilm+MB. The results prove that is possible to transmit light through the
tube even in the presence of MB and biofilm although a high attenuation of about 60% was measured depending on the
tested condition.
Como referenciar
BASSI, ROSANE; MYAKAWA, WALTER; NAVARRO, RICARDO S.; BAPTISTA, ALESSANDRA; RIBEIRO, MARTHA S.; NUNEZ, SILVIA C. Photodynamic Therapy to destroy pneumonia associated microorganisms using external irradiation source. In: DAI, TIANHONG (ed.). In: LIGHT-BASED DIAGNOSIS AND TREATMENT OF INFECTIOUS DISEASES, January 27 - February 01, 2018, San Francisco, California, USA. Proceedings... Bellingham, WA, USA: Society of Photo-optical Instrumentation Engineers, 2018. p. 1047917-1 - 1047917-5. (SPIE Proceedings Series, 10479). DOI: 10.1117/12.2290764. Disponível em: http://repositorio.ipen.br/handle/123456789/29107. Acesso em: 30 Dec 2025.
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