In vitro and in vivo toxicity evaluation of silver nanoparticles stabilized with gum arabic

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dc.contributor.authorMAZIERO, J.S.pt_BR
dc.contributor.authorCAVALCANTE, A.K.pt_BR
dc.contributor.authorMARTINI, G.A.pt_BR
dc.contributor.authorDAMASCENO, K.C.pt_BR
dc.contributor.authorORMENIO, M.B.pt_BR
dc.contributor.authorCAVALCANTE, B.K.pt_BR
dc.contributor.authorROGERO, S.O.pt_BR
dc.contributor.authorROGERO, J.R.pt_BR
dc.contributor.authorLUGAO, A.B.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoWORKSHOP ON ENVIRONMENTAL NANOTECHNOLOGY, 3rdpt_BR
dc.date.accessioned2019-08-28T14:35:43Z
dc.date.available2019-08-28T14:35:43Z
dc.date.eventoOctober 5-8, 2018pt_BR
dc.description.abstractDue to its properties such as size, varied shape, high surface area and high bactericidal properties, silver nanoparticles (AgNP) have been widely used in several sectors of the industry: bandages; inside food coolers, to retard spoilage; in antimicrobial insoles, to prevent odors; in air purifiers; in surgical instruments and etc [1] [2]. Considering the range of applications a great concern in the academic field, mainly ecotoxicological, as the potential impacts and risks that AgNP can cause to the environment and human health has increased. During the synthesis of AgNP it is necessary to use stabilizing agents such as gum arabic (GA), which is an exudate of dried gum, edible, from the stems and branches of Acacia senegal and A. seyal, rich in soluble fiber not viscous. GA has broad industrial use as stabilizer, thickening agent and emulsifier [3]. Based on these considerations, this work aimed to verify and compare the toxicity level of two GA-stabilized AgNP samples (Sample 1: AgNP at 147 ppm concentration, approximately 25 nm in size; and Sample 2: AgNP at concentration of 174 ppm with approximate size of 75 nm) using in vitro and in vivo assays. The in vitro cytotoxicity test was performed according to ISO 10993-5 by the neutral red uptake method in cells of the NCTC-L929 line, to obtain the IC50 (cytotoxicity index, which is the concentration of the substance causing it 50% mortality of exposed cells); and the in vivo acute ecotoxicity assay, according to the Brazilian standard ABNT NBR 12713, using Daphnia similis as the test organism to obtain EC50 (effective concentration that causes immobility in 50% of exposed organisms). The results obtained for Sample 1 were IC50 of 2.57 mg L-1 and EC50 of 4.40 μg L-1; and Sample 2: IC50 of 2.61 mg L-1 and EC50 of 6.55 μg L-1. These results demonstrated that aquatic organisms are much more sensitive to AgNP than cells in culture, raising the importance of conducting further studies related to the adversities that these nanoparticles can cause to the environment and human health. In addition, it is necessary to verify the disposal of the same in the environment, since in Brazil there are still no legislation that quantifies the permissible limits for this disposal.pt_BR
dc.format.extent49-49pt_BR
dc.identifier.citationMAZIERO, J.S.; CAVALCANTE, A.K.; MARTINI, G.A.; DAMASCENO, K.C.; ORMENIO, M.B.; CAVALCANTE, B.K.; ROGERO, S.O.; ROGERO, J.R.; LUGAO, A.B. In vitro and in vivo toxicity evaluation of silver nanoparticles stabilized with gum arabic. In: WORKSHOP ON ENVIRONMENTAL NANOTECHNOLOGY, 3rd, October 5-8, 2018, Sorocaba, SP. <b>Abstract...</b> p. 49-49. Disponível em: http://repositorio.ipen.br/handle/123456789/30127.
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcid0000-0002-2517-7772pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.orcidhttps://orcid.org/0000-0002-2517-7772
dc.identifier.orcidhttps://orcid.org/0000-0003-3396-6277
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30127
dc.local.eventoSorocaba, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleIn vitro and in vivo toxicity evaluation of silver nanoparticles stabilized with gum arabicpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorGISELA DE ASSIS MARTINI
ipen.autorKELME CARDOSO DAMASCENO
ipen.autorBEATRIZ KUCHINSKI CAVALCANTE
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorJOSE ROBERTO ROGERO
ipen.autorSIZUE OTA ROGERO
ipen.autorMATHEUS BEANI ORMENIO
ipen.autorADRIANA KUCHINSKI CAVALCANTE
ipen.autorJOANA DA SILVA MAZIERO
ipen.codigoautor10185
ipen.codigoautor14173
ipen.codigoautor14882
ipen.codigoautor339
ipen.codigoautor1118
ipen.codigoautor1266
ipen.codigoautor14332
ipen.codigoautor12073
ipen.codigoautor14163
ipen.contributor.ipenauthorGISELA DE ASSIS MARTINI
ipen.contributor.ipenauthorKELME CARDOSO DAMASCENO
ipen.contributor.ipenauthorBEATRIZ KUCHINSKI CAVALCANTE
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorJOSE ROBERTO ROGERO
ipen.contributor.ipenauthorSIZUE OTA ROGERO
ipen.contributor.ipenauthorMATHEUS BEANI ORMENIO
ipen.contributor.ipenauthorADRIANA KUCHINSKI CAVALCANTE
ipen.contributor.ipenauthorJOANA DA SILVA MAZIERO
ipen.date.recebimento19-08
ipen.event.datapadronizada2018pt_BR
ipen.identifier.ipendoc25921pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
sigepi.autor.atividadeROGERO, J.R.:1118:740:Npt_BR
sigepi.autor.atividadeROGERO, S.O.:1266:740:Npt_BR
sigepi.autor.atividadeCAVALCANTE, B.K.:14882:-1:Npt_BR
sigepi.autor.atividadeORMENIO, M.B.:14332:740:Npt_BR
sigepi.autor.atividadeDAMASCENO, K.C.:14173:740:Npt_BR
sigepi.autor.atividadeMARTINI, G.A.:10185:740:Npt_BR
sigepi.autor.atividadeCAVALCANTE, A.K.:12073:750:Npt_BR
sigepi.autor.atividadeMAZIERO, J.S.:14163:740:Spt_BR
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