Development of phosphate glass microspheres containing holmium for selective internal radiotherapy
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Materials Science Forum
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Selective internal radiotherapy is used to treat hepatocellular carcinoma. Glass
microspheres containing β-
particle emitter radionuclides are introduced into the liver close to the
tumor. The microspheres are trapped in the arterioles which feed the tumor. The irradiation with βparticles can cause the death of cancer cells. In this work the development of phosphate glass
microspheres containing holmium is proposed. 165Ho has a high cross section for neutron absorption
enabling the production of 166Ho which decays to 166Er by emitting a β- particle. The microspheres
were produced using the flame method and characterized by different techniques to evaluate their
potential use in radiotherapy. Microspheres with suitable morphology, size, density, and holmium
concentration were obtained.
Como referenciar
BARROS, E.C.; SENE, F.F.; MARTINELLI, J.R. Development of phosphate glass microspheres containing holmium for selective internal radiotherapy. Materials Science Forum, v. 775-776, p. 34-38, 2014. DOI: 10.4028/www.scientific.net/MSF.775-776.34. Disponível em: http://repositorio.ipen.br/handle/123456789/23750. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.