In vitro and in vivo response of PSMA-617 radiolabeled with CA and NCA lutetium-177

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dc.contributor.authorBOAS, CRISTIAN A.W.V.pt_BR
dc.contributor.authorSILVA, JEFFERSON de J.pt_BR
dc.contributor.authorDIAS, LUIS A.P.pt_BR
dc.contributor.authorFREIRE, MARIA R.B.pt_BR
dc.contributor.authorBALIEIRO, LUIZA M.pt_BR
dc.contributor.authorSANTOS, CAROLINA S.F. dospt_BR
dc.contributor.authorVIVALDINI, BIANCA F.pt_BR
dc.contributor.authorBENEDETTO, RAQUELpt_BR
dc.contributor.authorVIEIRA, DANIEL P.pt_BR
dc.contributor.authorPASSOS, PRISCILA de Q.S.pt_BR
dc.contributor.authorMARUMO, MARIA H.pt_BR
dc.contributor.authorTEIXEIRA, LUIS F.S.pt_BR
dc.contributor.authorARAUJO, ELAINE B. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-04-13T18:27:50Z
dc.date.available2022-04-13T18:27:50Z
dc.date.issued2022pt_BR
dc.description.abstractThe PSMA-targeted radionuclide therapy has been explored since 2015 with radioisotope lutetium-177, whose β− emission range is adequate for micrometastases treatment. This radioisotope is obtained by two different production routes that directly affect the specific activity of lutetium-177 (non-carrier added and carrier added) and, consequently, the specific activity of radiopharmaceuticals, like 177Lu-PSMA-617. The influence of the specific activity of lutetium-177 on the properties of the radiopharmaceutical PSMA-617 was evaluated through pre-clinical studies. The in vitro study pointed to a lower constant of dissociation with non-carrier added lutetium-177 due to the difference in the specific activity. However, competition and internalization assays resulted in similar results for both lutetium-177. Based on these pre-clinical experiments, the total in vitro tumor cell binding and tumor uptake in vivo were similar, with no influence of the specific activity of the 177Lu-PSMA-617. Regardless the specific activity did not directly affect tumor uptake, the tumor/non-target organs ratios were higher for the radiopharmaceutical labeled with carrier added lutetium-177, which had the lowest specific activity.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 18/12965-4pt_BR
dc.format.extent1-7pt_BR
dc.identifier.citationBOAS, CRISTIAN A.W.V.; SILVA, JEFFERSON de J.; DIAS, LUIS A.P.; FREIRE, MARIA R.B.; BALIEIRO, LUIZA M.; SANTOS, CAROLINA S.F. dos; VIVALDINI, BIANCA F.; BENEDETTO, RAQUEL; VIEIRA, DANIEL P.; PASSOS, PRISCILA de Q.S.; MARUMO, MARIA H.; TEIXEIRA, LUIS F.S.; ARAUJO, ELAINE B. de. In vitro and in vivo response of PSMA-617 radiolabeled with CA and NCA lutetium-177. <b>Applied Radiation and Isotopes</b>, v. 180, p. 1-7, 2022. DOI: <a href="https://dx.doi.org/10.1016/j.apradiso.2021.110064">10.1016/j.apradiso.2021.110064</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32952.
dc.identifier.doi10.1016/j.apradiso.2021.110064pt_BR
dc.identifier.issn0969-8043pt_BR
dc.identifier.orcid0000-0002-0007-534Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.orcidhttps://orcid.org/0000-0003-2852-6189
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.percentilfi32.5pt_BR
dc.identifier.percentilfiCiteScore46pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32952
dc.identifier.vol180pt_BR
dc.relation.ispartofApplied Radiation and Isotopespt_BR
dc.rightsopenAccesspt_BR
dc.subjectprostate
dc.subjectmembranes
dc.subjectantigens
dc.subjectlutetium 177
dc.subjectactivity levels
dc.subjectin vivo
dc.subjectin vitro
dc.subjectin vitro
dc.subjectradiopharmaceuticals
dc.subjectneoplasms
dc.titleIn vitro and in vivo response of PSMA-617 radiolabeled with CA and NCA lutetium-177pt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARIA RENATA VALENTE BRANDAO FREIRE
ipen.autorLUIZA MASCARENHAS BALIEIRO
ipen.autorCAROLINA SILVA FERREIRA DOS SANTOS
ipen.autorRAQUEL BENEDETTO
ipen.autorPRISCILA DE QUEIROZ SOUZA PASSOS
ipen.autorLUIZ FELIPE TEIXEIRA DA SILVA
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorMARIA HELENA BELLINI MARUMO
ipen.autorDANIEL PEREZ VIEIRA
ipen.autorBIANCA FRANCHESQUETI VIVALDINI
ipen.autorLUIS ALBERTO PEREIRA DIAS
ipen.autorJEFFERSON DE JESUS SILVA
ipen.autorCRISTIAN ANTONIO WIECZOREK VILLAS BOAS
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ipen.contributor.ipenauthorMARIA RENATA VALENTE BRANDAO FREIRE
ipen.contributor.ipenauthorLUIZA MASCARENHAS BALIEIRO
ipen.contributor.ipenauthorCAROLINA SILVA FERREIRA DOS SANTOS
ipen.contributor.ipenauthorRAQUEL BENEDETTO
ipen.contributor.ipenauthorPRISCILA DE QUEIROZ SOUZA PASSOS
ipen.contributor.ipenauthorLUIZ FELIPE TEIXEIRA DA SILVA
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorMARIA HELENA BELLINI MARUMO
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.contributor.ipenauthorBIANCA FRANCHESQUETI VIVALDINI
ipen.contributor.ipenauthorLUIS ALBERTO PEREIRA DIAS
ipen.contributor.ipenauthorJEFFERSON DE JESUS SILVA
ipen.contributor.ipenauthorCRISTIAN ANTONIO WIECZOREK VILLAS BOAS
ipen.date.recebimento22-04
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