Organic light-emitting diodes as an innovative approach for treating cutaneous leishmaniasis

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dc.contributor.authorCABRAL, FERNANDA V.pt_BR
dc.contributor.authorLIAN, CHENGpt_BR
dc.contributor.authorPERSHEYEV, SAYDULLApt_BR
dc.contributor.authorSMITH, TERRY K.pt_BR
dc.contributor.authorRIBEIRO, MARTHA S.pt_BR
dc.contributor.authorSAMUEL, IFOR D.W.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-12-30T11:48:21Z
dc.date.available2021-12-30T11:48:21Z
dc.date.issued2021pt_BR
dc.description.abstractAntimicrobial photodynamic therapy (APDT) has been studied as a noninvasive therapy for treating cutaneous leishmaniasis to overcome challenges with current treatment, such as toxicity, resistance, and need for in-patient hospital treatment. Organic light-emitting diodes (OLEDs) have emerged as an attractive technology that can provide wearable light-emitting materials that are conformable to human skin. This makes OLEDs ideal candidates for APDT by light-bandages for ambulatory care. In this work, suitable OLEDs are successfully developed to match the absorbance of three photosensitizers: methylene blue, new methylene blue, and 1,9-dimethyl-methylene blue to inactivate two Leishmania species in vitro: Leishmania major and Leishmania amazonensis. Parasites are treated either by LED (20 mW cm−2) or OLED (6.5 mW cm−2) at increasing photosensitizer concentrations at a radiant exposure of 50 J cm−2. 1,9-Dimethyl-methylene blue is the most potent photosensitizer, killing both strains at nanomolar concentrations. The effect of different intensities from the OLEDs (0.7, 1.5, and 6.5 mW cm−2) are also explored and it is shown that effective killing of Leishmania occurs even at a very low intensity. These findings demonstrate the great potential of OLEDs as a new approach for ambulatory treatment of cutaneous leishmaniasis by APDT.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipIDCNPq: 465763/2014-6pt_BR
dc.description.sponsorshipIDCAPES: 88887.364974/2019-00pt_BR
dc.format.extent1-9pt_BR
dc.identifier.citationCABRAL, FERNANDA V.; LIAN, CHENG; PERSHEYEV, SAYDULLA; SMITH, TERRY K.; RIBEIRO, MARTHA S.; SAMUEL, IFOR D.W. Organic light-emitting diodes as an innovative approach for treating cutaneous leishmaniasis. <b>Advanced Materials Technologies</b>, v. 6, n. 11, p. 1-9, 2021. DOI: <a href="https://dx.doi.org/10.1002/admt.202100395">10.1002/admt.202100395</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32586.
dc.identifier.doi10.1002/admt.202100395pt_BR
dc.identifier.fasciculo11pt_BR
dc.identifier.issn2365-709Xpt_BR
dc.identifier.orcid0000-0002-4203-1134pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4203-1134
dc.identifier.percentilfi82.17pt_BR
dc.identifier.percentilfiCiteScore93.00pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32586
dc.identifier.vol6pt_BR
dc.relation.ispartofAdvanced Materials Technologiespt_BR
dc.rightsopenAccesspt_BR
dc.subjectantibiotics
dc.subjectantimicrobial agents
dc.subjectlight emitting diodes
dc.subjectorganic compounds
dc.subjectparasites
dc.subjectphotosensitivity
dc.titleOrganic light-emitting diodes as an innovative approach for treating cutaneous leishmaniasispt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARTHA SIMOES RIBEIRO
ipen.autorFERNANDA VIANA CABRAL
ipen.codigoautor574
ipen.codigoautor12732
ipen.contributor.ipenauthorMARTHA SIMOES RIBEIRO
ipen.contributor.ipenauthorFERNANDA VIANA CABRAL
ipen.date.recebimento21-12
ipen.identifier.fi8.856pt_BR
ipen.identifier.fiCiteScore11.9pt_BR
ipen.identifier.ipendoc28354pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi6.000 ou mais
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreArtigo
relation.isAuthorOfPublication36215a53-0150-4910-91d7-9559717b62d7
relation.isAuthorOfPublication622f5d85-e9c4-40d7-a55f-873e2a346f55
relation.isAuthorOfPublication.latestForDiscovery622f5d85-e9c4-40d7-a55f-873e2a346f55
sigepi.autor.atividadeRIBEIRO, MARTHA S.:574:920:Npt_BR
sigepi.autor.atividadeCABRAL, FERNANDA V.:12732:920:Spt_BR
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