Variations in essential elements after malignant transformation of kidney epithelial tubular cells

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dc.contributor.authorBELLINI, MARIA H.pt_BR
dc.contributor.authorSOUZA, ALEXANDRE L. dept_BR
dc.contributor.authorSILVA, FABIO F. dapt_BR
dc.contributor.authorGUILHEN, SABINE N.pt_BR
dc.contributor.authorFERREIRA, RAFAEL V. de P.pt_BR
dc.contributor.authorARAUJO, LEANDRO G. dept_BR
dc.contributor.authorOLIVEIRA, JOAO E. dept_BR
dc.contributor.authorMARUMO, JULIO T.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-10-09T19:54:53Z
dc.date.available2020-10-09T19:54:53Z
dc.date.issued2020pt_BR
dc.description.abstractCell line-based research is a valuable tool for the study of cancer physiopathology and the discovery of new drugs for use in clinical practice. In this study, inductively coupled plasma mass spectrometry (ICP-MS) was used to estimate Ca, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn in epithelial tubular cells (HK-2) and kidney tumor cells (Caki-1 cells). The most relevant difference was a decrease in the contents of Ca, Cu, Fe, K, Mg, Mn, Na, P, S, and Zn. A significant accumulation of Co was also detected in Caki-1 cells. The fold change variation of each element concentration between HK-2 and Caki-1 cells was Ca (‒0.40), Co (1.37), Cu (‒0.68), Fe (‒0.56), K (‒0.40), Mg (‒0.41), Mn (-0.54), Na (‒0.33), P (‒0.31), S (‒0.26), and Zn (‒0.73). These findings indicate that the elements mainly affect the metabolic pathways of epithelial kidney cells. Thus, our findings open a new avenue for RCC target therapypt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 17/50332pt_BR
dc.format.extent114-117pt_BR
dc.identifier.citationBELLINI, MARIA H.; SOUZA, ALEXANDRE L. de; SILVA, FABIO F. da; GUILHEN, SABINE N.; FERREIRA, RAFAEL V. de P.; ARAUJO, LEANDRO G. de; OLIVEIRA, JOAO E. de; MARUMO, JULIO T. Variations in essential elements after malignant transformation of kidney epithelial tubular cells. <b>Medical & Clinical Research</b>, v. 5, n. 6, p. 114-117, 2020. DOI: <a href="https://dx.doi.org/10.33140/MCR.05.06.04">10.33140/MCR.05.06.04</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31420.
dc.identifier.doi10.33140/MCR.05.06.04pt_BR
dc.identifier.fasciculo6pt_BR
dc.identifier.issn2577-8005pt_BR
dc.identifier.orcid0000-0003-3010-9691pt_BR
dc.identifier.orcid0000-0002-6937-1120pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3010-9691
dc.identifier.orcidhttps://orcid.org/0000-0003-2604-1225
dc.identifier.orcidhttps://orcid.org/0000-0003-2852-6189
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.percentilfiCiteScoreSem Percentil CiteScore
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31420
dc.identifier.vol5pt_BR
dc.relation.ispartofMedical & Clinical Researchpt_BR
dc.rightsopenAccesspt_BR
dc.subjectkidneys
dc.subjectcarcinomas
dc.subjectelements
dc.subjecttransition elements
dc.subjecticp mass spectroscopy
dc.subjecttransformations
dc.subjecttumor cells
dc.subjectlyophilization
dc.titleVariations in essential elements after malignant transformation of kidney epithelial tubular cellspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorALEXANDRE LUIZ DE SOUZA
ipen.autorLEANDRO GOULART DE ARAUJO
ipen.autorJULIO TAKEHIRO MARUMO
ipen.autorJOAO EZEQUIEL DE OLIVEIRA
ipen.autorSABINE NEUSATZ GUILHEN
ipen.autorMARIA HELENA BELLINI MARUMO
ipen.codigoautor10606
ipen.codigoautor10132
ipen.codigoautor826
ipen.codigoautor425
ipen.codigoautor5931
ipen.codigoautor1242
ipen.contributor.ipenauthorALEXANDRE LUIZ DE SOUZA
ipen.contributor.ipenauthorLEANDRO GOULART DE ARAUJO
ipen.contributor.ipenauthorJULIO TAKEHIRO MARUMO
ipen.contributor.ipenauthorJOAO EZEQUIEL DE OLIVEIRA
ipen.contributor.ipenauthorSABINE NEUSATZ GUILHEN
ipen.contributor.ipenauthorMARIA HELENA BELLINI MARUMO
ipen.date.recebimento20-10
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.fiCiteScoreSem CiteScore
ipen.identifier.ipendoc27194pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication57d4b177-dc75-42ba-a652-954bf37bfac1
relation.isAuthorOfPublicationa0d4f881-138c-4443-9866-dc80ec84a861
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relation.isAuthorOfPublicationc3932232-0001-4122-bc0e-9109d11f8bec
relation.isAuthorOfPublication6a450cbf-91b1-4386-b4a8-7304afac99cc
relation.isAuthorOfPublication.latestForDiscovery6a450cbf-91b1-4386-b4a8-7304afac99cc
sigepi.autor.atividadeMARUMO, JULIO T.:826:1120:Npt_BR
sigepi.autor.atividadeOLIVEIRA, JOAO E. de:425:810:Npt_BR
sigepi.autor.atividadeARAUJO, LEANDRO G. de:10132:1120:Npt_BR
sigepi.autor.atividadeGUILHEN, SABINE N.:5931:510:Npt_BR
sigepi.autor.atividadeSOUZA, ALEXANDRE L. de:10606:-1:Npt_BR
sigepi.autor.atividadeBELLINI, MARIA H.:1242:810:Spt_BR
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