Development and production of radioactive sources for cancer tratment in Brazil

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dc.contributor.authorROSTELATO, MARIA E.C.M.pt_BR
dc.contributor.authorRELA, PAULO R.pt_BR
dc.contributor.authorZEITUNI, CARLOS A.pt_BR
dc.contributor.authorFEHER, ANSELMOpt_BR
dc.contributor.authorMANZOLI, JOSE E.pt_BR
dc.contributor.authorMOURA, JOAO A.pt_BR
dc.contributor.authorMOURA, EDUARDO S.pt_BR
dc.contributor.authorSILVA, CONSTANCIA P.G.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL CONFERENCE ON RECENT DEVELOPMENTS AND APPLICATIONS OF NUCLEAR TECHNOLOGIESpt_BR
dc.date.accessioned2014-11-19T10:35:51Zpt_BR
dc.date.accessioned2014-11-19T14:12:45Zpt_BR
dc.date.accessioned2015-04-01T12:41:16Z
dc.date.available2014-11-19T10:35:51Zpt_BR
dc.date.available2014-11-19T14:12:45Zpt_BR
dc.date.available2015-04-01T12:41:16Z
dc.date.eventoSeptember 15-17, 2008pt_BR
dc.description.abstractEvery year, the number of cancer patients increases in Brazil and some of these patients are treated with Brachytherapy using Iridium -192 wire sources and Iodine-125 seeds. Brachytherapy is a kind of lesion treatment based on the sources insertion in the tumor. These sources can be activated iridium wires or iodine seeds. During this process, the ionizing radiation destroys the malignant cells very efficiently. The Energy and Nuclear Research Institute – IPEN, which belongs to the Nuclear Energy National Commission – CNEN, established a program for the development of the technique and production of Iridium -192 wire sources and Iodine-125 seeds in Brazil. The purpose of this program is to develop the technique and to establish a laboratory for the production of Iridium – 192 sources and Iodine-125 seeds. This project target is to enable the country with the production of these sources, making the products accessible to clinics and hospitals, with low costs for the Brazilian people reality. With the purpose of settling a laboratory for Iridium –192 sources production, a wire activation method was developed and a hot cell for the wire manipulation, quality assurance and packaging was built. The wire activation was carried out in our nuclear reactor, IEAR1m. These sources are usually shaped as flexible wires 0.3mm diameter and 50.0cm long. The specific activity, for a low dose rate (LDR) therapy, is between 1mCi/cm and 4mCi/cm. The Iodine-125 seeds consist of a titanium capsule of 0.8 mm external diameter, 0.05mm wall thickness and 4.5mm long. The inner capsule houses a silver thread, 3.0mm long and 0.5mm diameter, containing the adsorbed 125-Iodine. The typical seed apparent activity is of 0.4mCi (14.8MBq), with a recommended variation of about 5% at most, in a same lot of seeds. During the project execution, the following methods were developed: the seed core (silver) cutting, the titanium tube cutting, the iodine immobilization through its deposition in silver substrate and the sealing of the seeds through welding process, so that the classification of the seeds, as sealed sources, and the leakage tests could be done according to the international norms.
dc.format.extent63pt_BR
dc.identifier.citationROSTELATO, MARIA E.C.M.; RELA, PAULO R.; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MANZOLI, JOSE E.; MOURA, JOAO A.; MOURA, EDUARDO S.; SILVA, CONSTANCIA P.G. Development and production of radioactive sources for cancer tratment in Brazil. In: INTERNATIONAL CONFERENCE ON RECENT DEVELOPMENTS AND APPLICATIONS OF NUCLEAR TECHNOLOGIES, September 15-17, 2008, Bialowieza, Poland. <b>Abstract...</b> p. 63. Disponível em: http://repositorio.ipen.br/handle/123456789/19312.
dc.identifier.orcidhttps://orcid.org/0000-0002-5054-0799
dc.identifier.orcidhttps://orcid.org/0000-0002-7303-6720
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/19312pt_BR
dc.local.eventoBialowieza, Polandpt_BR
dc.rightsopenAccesspt_BR
dc.subjectneoplasmspt_BR
dc.subjecttherapypt_BR
dc.subjectbrachytherapypt_BR
dc.subjectwirespt_BR
dc.subjectiridium 192pt_BR
dc.subjectiodine 125pt_BR
dc.subjectsealed sourcespt_BR
dc.titleDevelopment and production of radioactive sources for cancer tratment in Brazilpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorANSELMO FEHER
ipen.autorJOÃO AUGUSTO MOURA
ipen.autorCONSTANCIA PAGANO GONCALVES DA SILVA
ipen.autorEDUARDO SANTANA DE MOURA
ipen.autorJOSE EDUARDO MANZOLI
ipen.autorCARLOS ALBERTO ZEITUNI
ipen.autorPAULO ROBERTO RELA
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.codigoautor786
ipen.codigoautor6611
ipen.codigoautor26
ipen.codigoautor5860
ipen.codigoautor894
ipen.codigoautor944
ipen.codigoautor1522
ipen.codigoautor7
ipen.contributor.ipenauthorANSELMO FEHER
ipen.contributor.ipenauthorJOÃO AUGUSTO MOURA
ipen.contributor.ipenauthorCONSTANCIA PAGANO GONCALVES DA SILVA
ipen.contributor.ipenauthorEDUARDO SANTANA DE MOURA
ipen.contributor.ipenauthorJOSE EDUARDO MANZOLI
ipen.contributor.ipenauthorCARLOS ALBERTO ZEITUNI
ipen.contributor.ipenauthorPAULO ROBERTO RELA
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.date.recebimento09-05pt_BR
ipen.event.datapadronizada2008pt_BR
ipen.identifier.ipendoc13846pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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sigepi.autor.atividadeROSTELATO, MARIA E.C.M.:7:230:Spt_BR
sigepi.autor.atividadeRELA, PAULO R.:1522:240:Npt_BR
sigepi.autor.atividadeZEITUNI, CARLOS A.:944:420:Npt_BR
sigepi.autor.atividadeFEHER, ANSELMO:786:230:Npt_BR
sigepi.autor.atividadeMANZOLI, JOSE E.:894:220:Npt_BR
sigepi.autor.atividadeMOURA, JOAO A.:6611:230:Npt_BR
sigepi.autor.atividadeMOURA, EDUARDO S.:5860:230:Npt_BR
sigepi.autor.atividadeSILVA, CONSTANCIA P.G.:26:110:Npt_BR
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