In vitro cytotoxic data on Se-methylselenocysteine conjugated to dendritic poly(glycerol) against human squamous carcinoma cells

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dc.contributor.authorCORREA, NICOLI D.G.pt_BR
dc.contributor.authorSILVA, FELIPE D.pt_BR
dc.contributor.authorVIEIRA, DANIEL P.pt_BR
dc.contributor.authorSOARES, CARLOS R.J.pt_BR
dc.contributor.authorQUEIROZ, ALVARO A.A. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-05-05T11:23:45Z
dc.date.available2022-05-05T11:23:45Z
dc.date.issued2022pt_BR
dc.description.abstractPolymeric nanoparticles acting as sources of selenium (Se) are currently an interesting topic in cancer chemotherapy. In this study, polyglycerol dendrimer (DPGLy) was functionalized with seleno-methyl-selenocysteine (SeMeCys) by means of Steglich esterification with 4-dimethylaminopyridine/(l-ethyl-3-(3-dimethylaminopropyl)carbodiimide) (EDC/DMAP) and cerium chloride as cocatalyst in acetonitrile at quantitative yields of 98 ± 1%. The SeMeCys coupling DPGLy efficiency vs. time were determined by Fourier Transform infrared spectroscopy (FTIR) and ultraviolet–visible (UV–Vis) spectroscopy. The cytotoxic effects of SeMeCys–DPGLy on the Chinese Hamster ovary cell line (CHO-K1) and head and neck squamous cell carcinoma (HNSCC) cells line were assessed by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay. No signs of general toxicity of SeMeCys–DPGLy against CHO-K1 cells were detectable at which cell viability was greater than 98%. MTS assays revealed that SeMeCys–DPGLy reduced HNSCC cell viability and proliferation at higher doses and long incubation times.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDCNPq: 307609/2018-9pt_BR
dc.format.extent651-667pt_BR
dc.identifier.citationCORREA, NICOLI D.G.; SILVA, FELIPE D.; VIEIRA, DANIEL P.; SOARES, CARLOS R.J.; QUEIROZ, ALVARO A.A. de. In vitro cytotoxic data on Se-methylselenocysteine conjugated to dendritic poly(glycerol) against human squamous carcinoma cells. <b>Journal of Biomaterials Science, Polymer Edition</b>, v. 33, n. 5, p. 651-667, 2022. DOI: <a href="https://dx.doi.org/10.1080/09205063.2021.2008788">10.1080/09205063.2021.2008788</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33036.
dc.identifier.doi10.1080/09205063.2021.2008788pt_BR
dc.identifier.fasciculo5pt_BR
dc.identifier.issn0920-5063pt_BR
dc.identifier.orcid0000-0002-0007-534Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7982-1789
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.percentilfi50.3pt_BR
dc.identifier.percentilfiCiteScore65.5pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33036
dc.identifier.vol33pt_BR
dc.relation.ispartofJournal of Biomaterials Science, Polymer Editionpt_BR
dc.rightsopenAccesspt_BR
dc.subjectselenium
dc.subjectdendrimers
dc.subjectglycerol
dc.subjecttoxicity
dc.subjectcarcinomas
dc.subjectbioassay
dc.subjectin vitro
dc.titleIn vitro cytotoxic data on Se-methylselenocysteine conjugated to dendritic poly(glycerol) against human squamous carcinoma cellspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorFELIPE DOUGLAS DA SILVA
ipen.autorÁLVARO ANTONIO ALENCAR DE QUEIROZ
ipen.autorCARLOS ROBERTO JORGE SOARES
ipen.autorDANIEL PEREZ VIEIRA
ipen.autorNICOLI DOLORES GONCALVES CORREA
ipen.codigoautor14230
ipen.codigoautor7319
ipen.codigoautor509
ipen.codigoautor3158
ipen.codigoautor15213
ipen.contributor.ipenauthorFELIPE DOUGLAS DA SILVA
ipen.contributor.ipenauthorÁLVARO ANTONIO ALENCAR DE QUEIROZ
ipen.contributor.ipenauthorCARLOS ROBERTO JORGE SOARES
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.contributor.ipenauthorNICOLI DOLORES GONCALVES CORREA
ipen.date.recebimento22-05
ipen.identifier.fi3.6pt_BR
ipen.identifier.fiCiteScore6.4pt_BR
ipen.identifier.ipendoc28694pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
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relation.isAuthorOfPublication.latestForDiscovery4095d69a-3941-4cfa-837a-7000af3c8795
sigepi.autor.atividadeQUEIROZ, ALVARO A.A. de:7319:810:Npt_BR
sigepi.autor.atividadeSOARES, CARLOS R.J.:509:810:Npt_BR
sigepi.autor.atividadeVIEIRA, DANIEL P.:3158:810:Npt_BR
sigepi.autor.atividadeSILVA, FELIPE D.:14230:810:Npt_BR
sigepi.autor.atividadeCORREA, NICOLI D.G.:15213:810:Spt_BR
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