Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines
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Oncology Reports
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Head and neck squamous cell carcinoma is a
complex disease with several etiologic factors and different
molecular changes that may trigger certain events; it is also
globally one of the most common malignancies in this topography. Extracts from Viscum album L. (VA) (mistletoe) have
been used as adjuvant therapies with promising results in
several types of cancer, mainly in European countries. In vitro
studies have demonstrated that various types of VA may
have cytotoxicity in carcinoma cells, activating the apoptotic
cascade or leading cells to necrosis. This study aimed to verify
the effects of three types of VA extracts (Iscador Qu Spezial,
Iscador P and Iscador M) in squamous cell carcinoma of the
tongue cell lines SCC9 and SCC25, not previously studied. A
concentration of 0.3 mg/ml (IC50) of the drugs induced apoptosis, affecting gene expression and protein levels of AKT,
PTEN and CYCLIN D1. It was concluded that VA extracts
have a cytotoxic effect on SCC9 and SCC25 cell lines, but
while SCC9 cell line was more resistant to the action of the
drugs, Iscador Qu Spezial and Iscador M have higher cytotoxic
potential in both cell lines compared to Iscador P.
Como referenciar
KLINGBEIL, MARIA F.G.; XAVIER, FLAVIA C.A.; SARDINHA, LUIZ R.; SEVERINO, PATRICIA; MATHOR, MONICA B.; RODRIGUES, RODRIGO V.; PINTO JUNIOR, DECIO S. Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncology Reports, v. 30, n. 5, p. 2316-2322, 2013. DOI: 10.3892/or.2013.2732. Disponível em: http://repositorio.ipen.br/handle/123456789/4030. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.