Poloxamer-Driven drug delivery system for anti-inflammatory drugs using ssmall-angle neutron scattering approach
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Poloxamer-based drug delivery systems are widely used in the pharmaceutical
sector. The structural characterization of these systems is crucial for the development of
new drug delivery systems and for the optimization of their properties. In this study, we
utilized small-angle neutron scattering (SANS) to investigate the structures of poloxamerbased
drug delivery systems. The samples were measured using the SANS technique on
the VSANS-V16 instrument at Helmholtz-Zentrum Berlin (HZB), Germany. The samples
contained 20% poloxamer (P407) and 0.2% of a drug (ibuprofen, ketoprofen, diclofenac) in
deuterated water (D2O) for SANS. The samples varied in terms of temperature analysis
(25 ◦C, common storage temperature; 37 ◦C, human body temperature; 40 ◦C, fever temperature).
The data analysis involved modeling the data using a Python-based routine. The
model used consisted of an isotropic solution of polydisperse spherical micelles. The intensity
as a function of the scattering vector was modeled as the product of the form factor and
the interparticle structure factor, with the latter described within the local monodisperse
approximation regime. Additionally, a scattering contribution was observed, which was associated
with the presence of crystalline superstructures formed by micelles that organized
into a cubic structure. The data analysis provided important information about the system,
such as the average radius, the size distribution, and the thickness of the layer surrounding
the micellar core. The results will contribute to the development and optimization of new
drug delivery systems that are more effective and safer for medical applications.
Como referenciar
RHINOW, RODRIGO; FRANCO, MARGARETH K.K.D.; VOLLRATH, MONT K.; KELLERMANN, GUINTHER; YOKAICHIYA, FABIANO. Poloxamer-Driven drug delivery system for anti-inflammatory drugs using ssmall-angle neutron scattering approach. Gels, v. 11, n. 6, p. 1-14, 2025. DOI: 10.3390/gels11060410. Disponível em: https://repositorio.ipen.br/handle/123456789/49371. Acesso em: 04 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.