CMC and PVA hydrogel containing papain nanoparticles for drug delivery

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dc.contributor.authorLIMA, C.S.pt_BR
dc.contributor.authorVARCA, G.H.pt_BR
dc.contributor.authorOLIVEIRA, J.R.pt_BR
dc.contributor.authorNOGUEIRA, K.M.pt_BR
dc.contributor.authorSANTOS, F.A.pt_BR
dc.contributor.authorRIBEIRO, A.H.pt_BR
dc.contributor.authorLUGAO, A.B.pt_BR
dc.contributor.authorFREITAS, L.F.pt_BR
dc.contributor.authorROGERO, S.O.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoPAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2ndpt_BR
dc.date.accessioned2021-03-04T17:29:48Z
dc.date.available2021-03-04T17:29:48Z
dc.date.eventoMarch 4-7, 2020pt_BR
dc.description.abstractFour hydrogel formulations of Carboxymethylcellulose (CMC) and Poly (vinyl alcohol) (PVA) were prepared with native papain (AP and BP) and papain nanoparticles (AN and BN) for drug delivery. The formulations were evaluated for their preliminary stability, protein distribution in the matrix and cytotoxicity. Three methods for sterilization purposes were compared: irradiation by 60Co source, electron-beam and UV light. The preliminary stability test confirmed that the system was stable since there was no precipitation or alteration of the organoleptic properties of the samples in the evaluated period. The distribution of proteins in the hydrogel was very homogeneous in all the formulations. Quantification of the enzymatic activity of papain after contact with the gel showed that native papain maintained its activity high (86% and 93% for AP and BP gels, respectively), whereas there was a considerable drop in the activity of the papain nanoparticles to 60.54% and 69.44% for AP and BP gels, respectively. Such loss of activity is attributed to processing and/or process steps. The cell viability assay showed that the polymer matrix shows no cytotoxicity, corroborating with the literature, since the material is biocompatible. Thus, it is possible to affirm that the developed system presents potential for biomedical application, either as a vehicle of papain itself or for the transport of other drugs through complexation with papain nanoparticles. However, the need for further studies of stability, controlled release capacity and biocompatibility is required.pt_BR
dc.event.siglaPANNANOpt_BR
dc.identifier.citationLIMA, C.S.; VARCA, G.H.; OLIVEIRA, J.R.; NOGUEIRA, K.M.; SANTOS, F.A.; RIBEIRO, A.H.; LUGAO, A.B.; FREITAS, L.F.; ROGERO, S.O. CMC and PVA hydrogel containing papain nanoparticles for drug delivery. In: PAN-AMERICAN NANOTECHNOLOGY CONFERENCE, 2nd, March 4-7, 2020, Águas de Lindoia, SP. <b>Abstract...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/31869.
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcid0000-0002-6545-237Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3396-6277
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31869
dc.local.eventoÁguas de Lindoia, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleCMC and PVA hydrogel containing papain nanoparticles for drug deliverypt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorKAMILA MOREIRA NOGUEIRA
ipen.autorFELIPE ANTUNES SANTOS
ipen.autorLUCAS FREITAS DE FREITAS
ipen.autorSIZUE OTA ROGERO
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorANA PAULA HONORATO RIBEIRO
ipen.autorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorCAROLINE SANTOS ALVES DE LIMA
ipen.codigoautor12758
ipen.codigoautor8613
ipen.codigoautor14818
ipen.codigoautor1266
ipen.codigoautor339
ipen.codigoautor15059
ipen.codigoautor8726
ipen.codigoautor8661
ipen.codigoautor14945
ipen.contributor.ipenauthorKAMILA MOREIRA NOGUEIRA
ipen.contributor.ipenauthorFELIPE ANTUNES SANTOS
ipen.contributor.ipenauthorLUCAS FREITAS DE FREITAS
ipen.contributor.ipenauthorSIZUE OTA ROGERO
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorANA PAULA HONORATO RIBEIRO
ipen.contributor.ipenauthorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorCAROLINE SANTOS ALVES DE LIMA
ipen.date.recebimento21-03
ipen.event.datapadronizada2020pt_BR
ipen.identifier.ipendoc27640pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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relation.isAuthorOfPublication.latestForDiscovery00496d62-f664-40ae-bf64-e0db91a39f77
sigepi.autor.atividadeROGERO, S.O.:1266:740:Npt_BR
sigepi.autor.atividadeFREITAS, L.F.:14818:740:Npt_BR
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
sigepi.autor.atividadeSANTOS, F.A.:8613:720:Npt_BR
sigepi.autor.atividadeNOGUEIRA, K.M.:12758:740:Npt_BR
sigepi.autor.atividadeOLIVEIRA, J.R.:8726:740:Npt_BR
sigepi.autor.atividadeVARCA, G.H.:8661:740:Npt_BR
sigepi.autor.atividadeLIMA, C.S.:14945:740:Spt_BR
sigepi.autor.atividadeRIBEIRO, A.H.:15059:740:N
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