Photodynamic potentiality of hypocrellin B and its lanthanide complexes
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Journal of Optics, A: Pure and Applied Optics
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The search for new photosensitizers with strong absorption bands, fast elimination from the
body and high singlet oxygen generation quantum yield has been the subject of intensive
research over the past two decades. Perylenequinonoid pigments, such as hypocrellins and
hypericin, stand out among other photosensitizers due to their remarkable properties, which
fulfil these requirements. Besides, it was shown that hypocrellin B complexes with metal ions
possess even more notable optical and photodynamic properties. In this work, a study of the
photosensitizer hypocrellin B and its complexes formed with the lanthanide ions europium,
lanthanum and terbium, in ethanol and dimethyl sulfoxide solutions, was carried out by
spectroscopic methods, with the purpose of verifying its potentiality for use in photodynamic
therapy. The photobleaching of this molecule was also investigated, and our results show that,
under experimental conditions, there is a significant decrease in HB emission intensity after
about 30 min of exposure to white light. Moreover, lanthanide ions are able to modify
hypocrellin B energy levels, as well as its radioactive decay probabilities. Infrared emission
revealed the capacity of these complexes for generating singlet oxygen. Hypocrellin B complex
with lanthanum in ethanol showed the best results among the studied complexes regarding
optical characteristics of ideal photosensitizers, since it induced the larger redshift of about
30 nm, as well as enhanced HB singlet oxygen generation quantum yield of about 32%.
Como referenciar
TOFFOLI, D.J.; GOMES, L.; VIEIRA JUNIOR, N.D.; COURROL, L.C. Photodynamic potentiality of hypocrellin B and its lanthanide complexes. Journal of Optics, A: Pure and Applied Optics, v. 10, p. 104026-1 - 104026-8, 2008. DOI: 10.1088/1464-4258/10/10/104026. Disponível em: http://repositorio.ipen.br/handle/123456789/5046. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.