Reference values in whole blood of SJL/J mice using NAA
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2008
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INTERNATIONAL CONFERENCE ON NUCLEAR ANALYTICAL METHODS IN THE LIFE SCIENCES, 9th
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Resumo
One of the most used animals in biological field for experimentation is the mouse.
Particularly, the SJL/J mouse strain has been widely used as a model for different human
diseases and for experimental research, so the determination of metal concentrations of
clinical relevancy in whole blood may help to evaluate and compare the advantages of
different treatment schedules before tested in human beings. Considering that this strain is
susceptible to induced autoimmune diseases such as experimental autoimmune encephalitis,
inflammatory muscle disease and also presents a progressive muscular dystrophy, in this
study the Ca, Cl, K and Na concentrations were determined in whole blood samples using
Neutron Activation Analysis technique. To perform this investigation the whole blood
samples of two-month-old adult females (n = 7) and males (n = 4) that was originally obtained
from the Jackson Laboratory (Maine, USA) and further inbred at IPEN – CNEN/SP (São
Paulo, Brazil) were used. The samples were irradiated in the IEA R1 nuclear reactor, for few
minutes permitting the simultaneous activation of the selected elements resulting in reference
values for Ca, Cl, K and Na in whole blood. These data contribute for applications in
veterinary medicine related to biochemistry analyses of blood. Moreover, the correlation with
human blood estimation allows the choice of a better mouse strain as reference and for
experimental model.
Como referenciar
ZAMBONI, C.B.; SUZUKI, M.F.; METAIRON, S.; CARVALHO, M.D.F.; SANT'ANNA, O.A. Reference values in whole blood of SJL/J mice using NAA. In: INTERNATIONAL CONFERENCE ON NUCLEAR ANALYTICAL METHODS IN THE LIFE SCIENCES, 9th, September 7-12, 2008, Lisbon, Portugal. Abstract... Disponível em: http://repositorio.ipen.br/handle/123456789/19150. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.