Neutron activation analyses for investigation of antilonomic serum for caterpillars lonomia obliqua walker (Lepidoptera: saturniidae)
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Data de publicação:
2017
Autores IPEN
DALTON GIOVANNI NOGUEIRA DA SILVA
ILCA MARLI MOITINHO AMARAL
CIBELE BUGNO ZAMBONI
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60 YEARS OF IEA-R1: INTERNATIONAL WORKSHOP ON UTILIZATION OF RESEARCH REACTORS
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Resumo
Since 1996 the Butantan Institute (IBu, São Paulo city), in collaboration with the
Health Departments of some Brazilian states, produces serum antilonomic using the
caterpillars of the species L. obliqua from several regions of Brazil. However, no data
of their elemental composition to ensure that the antivenom produced (considering the different origins) maybe used to manufacture serum unchanged in the final product,
as regards the toxicity of inorganic elements. In this investigation, we intend
to check the elemental characterization of this antidote using Neutron Activation
Analyses technique (NAA). The NAA measurements were performed in the IEA-R1
nuclear reactor (IPEN/CNEN-SP, Brasil). Each sample was irradiated for 120s and
gamma counting endured 300s, HPGe detector (ORTEC-GEM 60195) coupled to
a MCA (ORTEC - 919E) used. The elements concentration were obtained using
the ATIVAÇÃO software. These quantitative analysis of the antilonomic serum will
generate data to evaluate the possibility of establishing a standard extract, which
would reduce costs in the antilonomic serum production process, as well as improvements
in serum production process antilonomic in the Butantan Institute, meeting
the standards of good manufacturing practices and good laboratory practice.
Como referenciar
LEAO, A.R.; ZAMBONI, C.B.; SILVA, D.G.N. da; MEDEIROS, I.M.M.A.; SIMONS, S.M. Neutron activation analyses for investigation of antilonomic serum for caterpillars lonomia obliqua walker (Lepidoptera: saturniidae). In: 60 YEARS OF IEA-R1: INTERNATIONAL WORKSHOP ON UTILIZATION OF RESEARCH REACTORS, November 28 - December 01, 2017, São Paulo, SP. Abstract... São Paulo, SP: Instituto de Pesquisas Energéticas e Nucleares, 2017. p. 16-17. Disponível em: http://repositorio.ipen.br/handle/123456789/28708. Acesso em: 17 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.