Evaluation of biokinetics and dosimetry in [131I]-NaI therapies
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Brazilian Journal of Radiation Sciences
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This study evaluate the possibility of restricting the current image quantification (ROI) from the whole body to a small area in thigh for therapy planning. Whole body planar images were obtained from 13 patients after the administration of 131I tracer dose, and OLINDA/EXM software was used for internal dose calculation. The average value of half-life time was 16.46 ± 3.45 h in whole body quantification, compared to 14.07 ± 2.89 h in thigh. The average absorbed dose in bone marrow from the whole body quantification was 0.0519 ± 0.0250 mGy/MBq, whilst the absorbed dose provided by the thigh quantification represented 87% of this value, with up to 95% in time reduction for dose calculation. Such doses become similar when a correction factor of 1.13 is applied in thigh dose results (p=0.67), which is within the variation coefficient assumed to internal dosimetry (20%). This study shows the possibility of a significant time reduction in internal dose calculation applied to therapy planning.
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LIMA, B.L.; ALMEIDA, J.S.; POTIENS, M.P.A.; PELISSONI, R.A.; SAPIENZA, M.T.; BUCHPIGUEL, C.A.; WILLEGAIGNON, J. Evaluation of biokinetics and dosimetry in [131I]-NaI therapies: quantification of whole body images versus thigh region. Brazilian Journal of Radiation Sciences, v. 8, n. 1A, p. 1-13, 2020. DOI: 10.15392/bjrs.v8i1A.1082. Disponível em: http://repositorio.ipen.br/handle/123456789/31474. Acesso em: 30 Dec 2025.
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