Light-based non-thermal therapy
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Biophysical Reviews
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Light-based non-thermal therapies are evolving as promising
non-invasive and cost-effective medical technologies.
These therapeutic platforms mainly encompass photobiomodulation
(PBM) and photodynamic therapy (PDT), which
use visible or near infrared (NIR) light to induce biological
responses without any significant heating effects. For PBM,
it is most commonly used red or NIR light to optimize light
penetration into biological tissues. The photon absorption by
natural chromophores at these spectral regions cause photophysical
and photochemical reactions inside cells that trigger
several biological effects such as to accelerate wound healing,
reduce inflammation and relief pain, depending on light
parameters and target tissue. On the other hand, PDT makes
use of photoactivated drugs, also called as photosensitizers,
which absorb light to induce chemical reactions that kill
microbial or cancer cells by oxidative stress. Our group have been investigating the mechanisms and several
applications of PBM and antimicrobial PDT (APDT)
for almost 20 years. In this lecture I will share our experience
in the area to discuss how PBM and APDT could be
used to revolutionize health care in the photonics era. An
integrated perspective from the basic mechanisms, preclinical
and clinical trials for both therapies will be presented,
including PBM on cancer management and APDT against
drug-resistant pathogens. The lecture will also highlight
future perspectives.
Como referenciar
RIBEIRO, MARTHA S. Light-based non-thermal therapy: from basis to clinical applications. Biophysical Reviews, v. 13, n. 6, p. 1491-1491, 2021. DOI: 10.1007/s12551-021-00844-3. Disponível em: http://repositorio.ipen.br/handle/123456789/32894. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.