Effects of a moderate iron overload and its interaction with yacon flour, and/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats
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Food Chemistry
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The effect of moderate Fe overload in the diet and its interaction with phytate, and/or yacon flour (YF), recognized
as an inhibitor, and facilitator, of Fe absorption, respectively, was evaluated in healthy rats. For this
purpose the following parameters were analyzed: (1) apparent iron (Fe), copper (Cu) and zinc (Zn) absorption;
(2) blood Fe; (3) blood lipids (cholesterol, tryacylglicerol); (4) blood AST and ALT; (5) liver histology (histopathology,
hemosiderin depots, apoptosis index; (6) liver fatty acid incorporation; (7) liver antioxidant enzyme
activity. Moderate Fe overload may cause change in some liver markers (hemosiderin depots, apoptosis index
and GPx) and blood lipids (total cholesterol and VLDL) and the interaction with yacon flour, and phytate, in the
Fe overloaded diets may exert a protective effect on these alterations.
Como referenciar
COCATO, MARIA L.; LOBO, ALEXANDRE R.; AZEVEDO-MARTINS, ANNA K.; MANCINI FILHO, JORGE; SA, LILIAN R.M. de; COLLI, CELIA. Effects of a moderate iron overload and its interaction with yacon flour, and/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats. Food Chemistry, v. 285, p. 171-179, 2019. DOI: 10.1016/j.foodchem.2019.01.142. Disponível em: http://repositorio.ipen.br/handle/123456789/30521. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.