Optical Coherence Tomography for blood glucose monitoring through signal attenuation
Carregando...
Data
Data de publicação
2016
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE, 20th
ODS
Exportar
Resumo
Development of non-invasive techniques for glucose monitoring is crucial to improve glucose control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative for
portable glucometers, since it uses light to probe samples. Changes in the object of interest can alter the intensity of light
returning from the sample and, through it, one can estimate the sample's attenuation coefficient (μt) of light. In this work,
we aimed to explore the behavior of μt of mouse’s blood under increasing glucose concentrations. Different samples
were prepared in four glucose concentrations using a mixture of heparinized blood, phosphate buffer saline and glucose.
Blood glucose concentrations were measured with a blood glucometer, for reference. We have also prepared other
samples diluting the blood in isotonic saline solution to check the effect of a higher multiple-scattering component on the
ability of the technique to differentiate glucose levels based on μt. The OCT system used was a commercial Spectral
Radar OCT with 930 nm central wavelength and spectral bandwidth (FWHM) of 100 nm. The system proved to be
sensitive for all blood glucose concentrations tested, with good correlations with the obtained attenuation coefficients. A
linear tendency was observed, with an increase in attenuation with higher values of glucose. Statistical difference was
observed between all groups (p<0.001). This work opens the possibility towards a non-invasive diagnostic modality
using OCT for glycemic control, which eliminates the use of analytes and/or test strips, as in the case with commercially
available glucometers.
Como referenciar
PRETTO, LUCAS R. de; YOSHIMURA, TANIA M.; RIBEIRO, MARTHA S.; FREITAS, ANDERSON Z. de. Optical Coherence Tomography for blood glucose monitoring through signal attenuation. In: IZATT, JOSEPH A. (ed.); FUJIMOTO, JAMES G. (ed.); TUCHIN, VALERY V. (ed.). In: OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE, 20th, February 13, 2016, San Francisco, California, USA. Proceedings... p. 96973F-1 - 96973F-9. (SPIE Proceedings Series, 9697). DOI: 10.1117/12.2213347. Disponível em: http://repositorio.ipen.br/handle/123456789/27115. Acesso em: 31 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.