Bacterial photodynamic inactivation mediated by methylene blue and red light is enhanced by synergistic effect of potassium iodide

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dc.contributor.authorVECCHIO, DANIELApt_BR
dc.contributor.authorGUPTA, ASHEESHpt_BR
dc.contributor.authorHUANG, LIYIpt_BR
dc.contributor.authorLANDI, GIACOMOpt_BR
dc.contributor.authorAVCI, PINARpt_BR
dc.contributor.authorRODAS, ANDREApt_BR
dc.contributor.authorHAMBLIN, MICHAEL R.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-04-29T13:15:56Z
dc.date.available2020-04-29T13:15:56Z
dc.date.issued2015pt_BR
dc.description.abstractThe inexorable increase of antibiotic resistance occurring in different bacterial species is increasing the interest in developing new antimicrobial treatments that will be equally effective against multidrug-resistant strains and will not themselves induce resistance. One of these alternatives may be photodynamic inactivation (PDI), which uses a combination of nontoxic dyes, called photosensitizers (PS), excited by harmless visible light to generate reactive oxygen species (ROS) by type 1 (radical) and type 2 (singlet oxygen) pathways. In this study, we asked whether it was possible to improve the efficacy of PDI in vitro and in vivo by addition of the inert salt potassium iodide (KI) to a commonly investigated PS, the phenothiazinium dye methylene blue (MB). By adding KI, we observed a consistent increase of red light-mediated bacterial killing of Gram-positive and Gram-negative species in vitro and in vivo. In vivo, we also observed less bacterial recurrence in wounds in the days posttreatment. The mechanism of action is probably due to formation of reactive iodine species that are produced quickly with a short lifetime. This finding may have a relevant clinical impact by reducing the risk of amputation and, in some cases, the risk of death, leading to improvement in the care of patients affected by localized infections.pt_BR
dc.format.extent5203-5212pt_BR
dc.identifier.citationVECCHIO, DANIELA; GUPTA, ASHEESH; HUANG, LIYI; LANDI, GIACOMO; AVCI, PINAR; RODAS, ANDREA; HAMBLIN, MICHAEL R. Bacterial photodynamic inactivation mediated by methylene blue and red light is enhanced by synergistic effect of potassium iodide. <b>Antimicrobial Agents and Chemotherapy</b>, v. 59, n. 9, p. 5203-5212, 2015. DOI: <a href="https://dx.doi.org/10.1128/AAC.00019-15">10.1128/AAC.00019-15</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31145.
dc.identifier.doi10.1128/AAC.00019-15pt_BR
dc.identifier.fasciculo9pt_BR
dc.identifier.issn0066-4804pt_BR
dc.identifier.percentilfi84.69pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31145
dc.identifier.vol59pt_BR
dc.relation.ispartofAntimicrobial Agents and Chemotherapypt_BR
dc.rightsclosedAccesspt_BR
dc.subjectbacteria
dc.subjectinactivation
dc.subjectphotosensitivity
dc.subjectmethylene blue
dc.subjectpotassium iodides
dc.subjectin vivo
dc.subjectin vitro
dc.subjectantibiotics
dc.subjectdrugs
dc.subjectlight sources
dc.subjecttherapy
dc.subjectreagents
dc.titleBacterial photodynamic inactivation mediated by methylene blue and red light is enhanced by synergistic effect of potassium iodidept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorANDREA CECILIA DORION RODAS
ipen.codigoautor1703
ipen.contributor.ipenauthorANDREA CECILIA DORION RODAS
ipen.date.recebimento20-04
ipen.identifier.fi4.415pt_BR
ipen.identifier.ipendoc26923pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreArtigo
relation.isAuthorOfPublication0b208ad2-c765-4c4d-ae39-7c24fd6a8d55
relation.isAuthorOfPublication.latestForDiscovery0b208ad2-c765-4c4d-ae39-7c24fd6a8d55
sigepi.autor.atividadeRODAS, ANDREA:1703:720:Npt_BR
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