Ascertaining serum levels of trace elements in melanoma patients using PIXE and HR-ICPMS
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Nuclear Instruments and Methods in Physics Research, B
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Melanoma is a serious and deadly form of skin cancer. However, patients’ chances of survival and recovery are considerably increased when it is diagnosed and treated in its early stages. In this study, trace element concentrations in serum samples from patients with melanoma were measured using PIXE (Proton
Induced X-ray Emission) and HR-ICPMS (High-Resolution Inductively Coupled Plasma Mass Spectrometry), with the purpose of correlating these concentrations with the disease. Blood samples from 30 melanoma patients and 116 healthy donors were collected at São Paulo Hospital (protocol CEP 1036/08
UNIFESP). Relevant clinical information on the patients has also been included in the statistical analysis.
Analysis of the control group showed different P and Mg concentrations in individuals above and below
40 years of age. P, S, Ca, Cu and Zn concentrations in healthy individuals differed according to gender,
highlighting the necessity to include age and gender variables in the case-control analysis. There were
also differences in K, S, Ca and Se concentrations between the control and melanoma groups.
Como referenciar
BERNARDES, S.; TABACNIKS, M.H.; SANTOS, I.D.A.O.; OLIVEIRA, A.F.; SHIE, J.N.; SARKIS, J.E.S.; OLIVEIRA, T. Ascertaining serum levels of trace elements in melanoma patients using PIXE and HR-ICPMS. Nuclear Instruments and Methods in Physics Research, B, v. 318, p. 178-181, 2014. DOI: 10.1016/j.nimb.2013.06.064. Disponível em: http://repositorio.ipen.br/handle/123456789/8534. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.