Study of ProtoPorphyrin IX elimination by body excreta
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Journal of Fluorescence
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This paper describes the elimination of porphyrins by feces. It was demonstrated that porphyrin accumulates substantially more in tumors than in normal tissues,
and consequently more PPIX reaches the blood of patients
and animals with tumors, and then, it needs to be eliminated.
The fluorescence of feces revealed that there are large
amounts of PPIX in the excreta of animals with cancer
comparing with healthy animals. The autofluorescence of
feces porphyrin extracted with acetone was analyzed using
fluorescence spectroscopy of animals inoculated with
DU145 cells into the prostate and healthy animals to monitor the PPIX concentration. Emission spectra were obtained
by exciting the samples at 405 nm. Significant differences
were observed in autofluorescence intensities measured in
the 575–725 nm spectral regions for the studied groups. The
results showed a noninvasive, simple, rapid and sensitive
method to detect cancer by feces analysis.
Como referenciar
SILVA, FLAVIA R.O.; NABESHIMA, CAMILA T.; BELLINI, MARIA H.; SCHOR, NESTOR; VIEIRA JUNIOR, NILSON D.; COURROL, LILIA C. Study of ProtoPorphyrin IX elimination by body excreta: a new noninvasive cancer diagnostic method. Journal of Fluorescence, v. 23, n. 1, p. 131-135, 2013. DOI: 10.1007/s10895-012-1126-1. Disponível em: http://repositorio.ipen.br/handle/123456789/4107. Acesso em: 30 Dec 2025.
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