Nanomaterials for enhanced photodynamic therapy
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Photodynamic therapy: from basic science to clinical research
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Photodynamic therapy is a non-invasive option for eliminating superficial
tumors and to control infections. However, despite some protocols are already
approved for the clinic, PDT applications could be much broader if some of its
main hindrances were overcome. For instance, the most efficient photosensitizers
are hydrophobic, so if one injects them intravenously they tend to aggregate and
to be internalized by phagocytes in the blood, impairing the delivery to the target
site. In addition, visible light has a limited penetration in tissues, therefore the main
applications of PDT are limited to superficial tumors unless an invasive procedure is
used for the light to reach deeper sites. Another setback is the hypoxia that commonly
happens in tumors, hindering the full potential of PDT as it depends on a
constant oxygen supply. In this chapter the reader will find some strategies based
on Nanotechnology to overcome these and other obstacles for PDT to reach its full
clinical potential, i.e. hypoxia-reverting protocols, X-ray-driven PDT, Cherenkov
radiation-driven PDT, and active tumor-targeting.
Como referenciar
FREITAS, LUCAS F. de. Nanomaterials for enhanced photodynamic therapy. In: INADA, NATALIA M. (ed.). Photodynamic therapy: from basic science to clinical research. London, UK: IntechOpen, 2021. , cap. 12. p. 1-16. DOI: 10.5772/intechopen.94255. Disponível em: http://repositorio.ipen.br/handle/123456789/32229. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.