Ovarian transfer following irradiation as an alternative to restore reproductive functions
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2009
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st
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Resumo
Assisted reproduction technologies are essential for restoring reproductive functions, especially
in ovary cancer cases, which besides impairing fertility; present the highest lethality amongst
gynecological diseases. Classical treatment involves surgery, radiotherapy and chemotherapy, and in
young women, the recommended treatment is the removal of the affected ovary, leading to physical,
psychological and emotional problems. An alternative would be the ovarian transfer after the treatment.
However, there are no data in the literature about experiments specifically designed to investigate the
interference of this procedure on reproductive functions. In the present work, we used the C57BL/6Unib
and B6CF1 hybrid mice strains to evaluate the viability of ovarian transfer before and after irradiation, as
well as possible differences in radiosensitivity between the strains. To do so, female mice from both
strains were irradiated with 4 Gy and submitted to either partial or total ovarian transfer form healthy
donors. After the surgery, the animals were mated and the results obtained so far for mating 7 days after
the procedure indicate that irradiation promoted a significant decrease in fertility (p=0.0127). Also, our
data show that the recovery of fertility is proportional to the amount of grafted ovarian tissue.
Furthermore, there seems to be differences in radiosensitivity, from genetic origin, between the two mice
strain, since, after irradiation, the hybrid mice had bigger litters than the donor strain.
Como referenciar
SALGADO, ANDREIA R.; PASSOS, LUIZ A.C.; SPENCER, PATRICK J.; GIMENES, ANA P.; DIAS, VIVIANE L.; NASCIMENTO, NANCI. Ovarian transfer following irradiation as an alternative to restore reproductive functions. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/16580. Acesso em: 13 Mar 2025.
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