Ovarian transfer following irradiation as an alternative to restore reproductive functions

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dc.contributor.authorSALGADO, ANDREIA R.pt_BR
dc.contributor.authorPASSOS, LUIZ A.C.pt_BR
dc.contributor.authorSPENCER, PATRICK J.pt_BR
dc.contributor.authorGIMENES, ANA P.pt_BR
dc.contributor.authorDIAS, VIVIANE L.pt_BR
dc.contributor.authorNASCIMENTO, NANCIpt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1stpt_BR
dc.date.accessioned2014-11-17T18:19:38Zpt_BR
dc.date.accessioned2014-11-18T18:26:31Zpt_BR
dc.date.accessioned2015-04-02T04:31:07Z
dc.date.available2014-11-17T18:19:38Zpt_BR
dc.date.available2014-11-18T18:26:31Zpt_BR
dc.date.available2015-04-02T04:31:07Z
dc.date.eventoSeptember 27 - October 2, 2009pt_BR
dc.description.abstractAssisted reproduction technologies are essential for restoring reproductive functions, especially in ovary cancer cases, which besides impairing fertility; present the highest lethality amongst gynecological diseases. Classical treatment involves surgery, radiotherapy and chemotherapy, and in young women, the recommended treatment is the removal of the affected ovary, leading to physical, psychological and emotional problems. An alternative would be the ovarian transfer after the treatment. However, there are no data in the literature about experiments specifically designed to investigate the interference of this procedure on reproductive functions. In the present work, we used the C57BL/6Unib and B6CF1 hybrid mice strains to evaluate the viability of ovarian transfer before and after irradiation, as well as possible differences in radiosensitivity between the strains. To do so, female mice from both strains were irradiated with 4 Gy and submitted to either partial or total ovarian transfer form healthy donors. After the surgery, the animals were mated and the results obtained so far for mating 7 days after the procedure indicate that irradiation promoted a significant decrease in fertility (p=0.0127). Also, our data show that the recovery of fertility is proportional to the amount of grafted ovarian tissue. Furthermore, there seems to be differences in radiosensitivity, from genetic origin, between the two mice strain, since, after irradiation, the hybrid mice had bigger litters than the donor strain.
dc.event.siglaINAC; ENAN; ENFIR; ENINpt_BR
dc.identifier.citationSALGADO, ANDREIA R.; PASSOS, LUIZ A.C.; SPENCER, PATRICK J.; GIMENES, ANA P.; DIAS, VIVIANE L.; NASCIMENTO, NANCI. Ovarian transfer following irradiation as an alternative to restore reproductive functions. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. <b>Proceedings...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/16580.
dc.identifier.orcidhttps://orcid.org/0000-0001-8949-7735
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/16580pt_BR
dc.local.eventoRio de Janeiro, RJpt_BR
dc.publisherSao Paulo: ABEN, 2009pt_BR
dc.rightsopenAccesspt_BR
dc.subjectbiological radiation effectspt_BR
dc.subjectcobalt 60pt_BR
dc.subjectdose-response relationshipspt_BR
dc.subjectexperimental datapt_BR
dc.subjectfertilitypt_BR
dc.subjectgamma radiationpt_BR
dc.subjectgraftspt_BR
dc.subjectmicept_BR
dc.subjectovariespt_BR
dc.subjectradiation dosespt_BR
dc.subjectradiosensitivitypt_BR
dc.subjectreproductionpt_BR
dc.titleOvarian transfer following irradiation as an alternative to restore reproductive functionspt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorNANCI DO NASCIMENTO
ipen.autorPATRICK JACK SPENCER
ipen.codigoautor411
ipen.codigoautor910
ipen.contributor.ipenauthorNANCI DO NASCIMENTO
ipen.contributor.ipenauthorPATRICK JACK SPENCER
ipen.date.recebimento09-10pt_BR
ipen.event.datapadronizada2009pt_BR
ipen.identifier.ipendoc15165pt_BR
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication53eed426-0bd7-4230-8b8c-f48795fad345
relation.isAuthorOfPublication4eb7939e-aeea-4991-8525-b3d05ac27364
relation.isAuthorOfPublication.latestForDiscovery4eb7939e-aeea-4991-8525-b3d05ac27364
sigepi.autor.atividadeSPENCER, PATRICK J.:910:820:Npt_BR
sigepi.autor.atividadeNASCIMENTO, NANCI:411:820:Npt_BR
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